A peripheral component interconnect express-based scalable and highly integrated pulsed spectrometer for solution state dynamic nuclear polarization

The Review of Scientific Instruments
Yugui HeChaoyang Liu

Abstract

High sensitivity, high data rates, fast pulses, and accurate synchronization all represent challenges for modern nuclear magnetic resonance spectrometers, which make any expansion or adaptation of these devices to new techniques and experiments difficult. Here, we present a Peripheral Component Interconnect Express (PCIe)-based highly integrated distributed digital architecture pulsed spectrometer that is implemented with electron and nucleus double resonances and is scalable specifically for broad dynamic nuclear polarization (DNP) enhancement applications, including DNP-magnetic resonance spectroscopy/imaging (DNP-MRS/MRI). The distributed modularized architecture can implement more transceiver channels flexibly to meet a variety of MRS/MRI instrumentation needs. The proposed PCIe bus with high data rates can significantly improve data transmission efficiency and communication reliability and allow precise control of pulse sequences. An external high speed double data rate memory chip is used to store acquired data and pulse sequence elements, which greatly accelerates the execution of the pulse sequence, reduces the TR (time of repetition) interval, and improves the accuracy of TR in imaging sequences. Using clock phase-shif...Continue Reading

References

May 26, 1999·Journal of Magnetic Resonance·M Alecci, D J Lurie
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jan H Ardenkjaer-LarsenKlaes Golman
Jul 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Klaes GolmanMikkel Thaning
Apr 7, 2007·The Review of Scientific Instruments·Kazuyuki Takeda
Jul 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S J KohlerR E Hurd
Sep 18, 2007·The Journal of Chemical Physics·Brandon D Armstrong, Songi Han
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Albert P ChenDaniel B Vigneron
Jan 30, 2008·Journal of Magnetic Resonance·Brandon D ArmstrongSongi Han
Feb 26, 2008·Journal of the American Chemical Society·Peter HöferMarina Bennati
Oct 7, 2009·Journal of the American Chemical Society·Marcel ReeseMarina Bennati
May 8, 2010·Physical Chemistry Chemical Physics : PCCP·Nikolas Pomplun, Steffen J Glaser
May 13, 2010·Physical Chemistry Chemical Physics : PCCP·Alexander KrahnChristian Griesinger
Jun 3, 2010·Physical Chemistry Chemical Physics : PCCP·Björn C DollmannKerstin Münnemann
Sep 8, 2011·Physical Chemistry Chemical Physics : PCCP·P J M van BentumA P M Kentgens
Sep 29, 2011·IEEE Transactions on Medical Imaging·Pascal P StangGreig C Scott
Mar 30, 2012·Physical Chemistry Chemical Physics : PCCP·Egor A NasibulovHans-Martin Vieth
Sep 15, 2012·Journal of Magnetic Resonance·Albert A SmithRobert G Griffin
Aug 16, 2013·Science Translational Medicine·Sarah J NelsonJonathan A Murray
Oct 3, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·John M FranckSongi Han

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