A peripheral primitive neuroectodermal tumor with generalized bone metastases in a puppy

Veterinary Pathology
H E V De CockR J Higgins

Abstract

A peripheral primitive neuroectodermal tumor (pPNET), most consistent with a human Ewing's sarcoma, is described in a 5-month-old male Australian Shepherd puppy. The first tumor site detected was in the left frontal bone of the skull with apparent subsequent rapid metastases to multiple sites in the axial and appendicular skeleton and bone marrow, kidneys, and perihyphophyseal meninges. Radiographically, all bone lesions were lytic and there was also a humeral bone fracture. Histologically, the tumor was diagnosed as a small round blue cell tumor. At this stage, the differential diagnosis included a lymphoma, rhabdomyosarcoma, and a PNET of the peripheral nervous system. However, the cells had positive expression of triple neurofilament antigens as detected immunocytochemically. The cells were negative for a broad panel of canine-specific leucocyte cell marker antigens for desmin, smooth muscle actin, synaptophysin, and CD99. Ultrastructurally, the cells contained occasional dense core neurosecretory granules and intermediate filaments with intercellular desmosomal-like junctions and abundant glycogen clusters. Based on the age of the dog, the clinical history, the distribution of gross lesions, histologic characteristics of a ...Continue Reading

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Citations

May 30, 2013·Journal of Comparative Pathology·J JungingerF Seehusen
Aug 25, 2011·Journal of Comparative Pathology·S KleinschmidtP Wohlsein
Dec 19, 2008·Journal of Comparative Pathology·S A HeadleyA Sukura
Nov 21, 2007·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Gabriela SeilerUrs Giger
Nov 11, 2011·Journal of Medical Primatology·Wijit BanlunaraHiroyuki Nakayama
May 25, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Paul R FacemireShelley P Honnold
Mar 6, 2009·Veterinary Pathology·J M MartinK A Fischer
Nov 8, 2011·Journal of the American Animal Hospital Association·Laura A Snyder, Helen Michael
Oct 6, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Yu-Han HsiehWen-Ta Li
Nov 17, 2019·International Journal of Molecular Sciences·Jana SchneiderMartin S Staege

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Methods Mentioned

BETA
electrophoresis
transmission electron microscopy

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