PMID: 8942994Nov 26, 1996Paper

A peroxidase related to the mammalian antimicrobial protein myeloperoxidase in the Euprymna-Vibrio mutualism

Proceedings of the National Academy of Sciences of the United States of America
V M WeisM J McFall-Ngai

Abstract

Many animal-bacteria cooperative associations occur in highly modified host organs that create a unique environment for housing and maintaining the symbionts. It has been assumed that these specialized organs develop through a program of symbiosis-specific or -enhanced gene expression in one or both partners, but a clear example of this process has been lacking. In this study, we provide evidence for the enhanced production of an enzyme in the symbiotic organ of the squid Euprymna scolopes, which harbors a culture of the luminous bacterium Vibrio fischeri. Our data show that this enzyme has a striking biochemical similarity to mammalian myeloperoxidase (MPO; EC 1.11.17), an antimicrobial dianisidine peroxidase that occurs in neutrophils. MPO and the squid peroxidase catalyze the same reaction, have similar apparent subunit molecular masses, and a polyclonal antibody to native human MPO specifically localized a peroxidase-like protein to the bacteria-containing regions of the symbiotic organ. We also provide evidence that a previously described squid cDNA encodes the protein (LO4) that is responsible for the observed dianisidine peroxidase activity. An antibody made against a fragment of LO4 immunoprecipiated dianisidine peroxid...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 25, 1992·Nature·R F Fisher, S R Long
Jan 1, 1991·Advances in Space Biology and Medicine·A I Grigoriev, A D Egorov
Nov 1, 1960·Stain Technology·K C RICHARDSONE H FINKE
Oct 1, 1992·The New Phytologist·Ann M Hirsch

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Citations

Oct 12, 2001·International Journal of Hematology·W M Nauseef
Jul 30, 1999·Developmental and Comparative Immunology·M W Johansson
Sep 16, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M J McFall-Ngai
Dec 21, 2000·Current Opinion in Microbiology·M J McFall-Ngai, E G Ruby
Nov 14, 2012·Nature Reviews. Microbiology·Spencer V Nyholm, Joerg Graf
Jul 21, 2004·Nature Reviews. Microbiology·Spencer V Nyholm, Margaret J McFall-Ngai
Aug 31, 2000·Applied and Environmental Microbiology·J Doino Lemus, M J McFall-Ngai
Nov 5, 2005·Applied and Environmental Microbiology·Michael S GoodsonMargaret J McFall-Ngai
Mar 14, 2000·Journal of Bacteriology·K L Visick, M J McFall-Ngai
Aug 24, 2002·Journal of Bacteriology·Cindy R DeLoneyKaren L Visick
Jan 19, 1999·Annual Review of Cell and Developmental Biology·T Wilson, J W Hastings
Sep 20, 2015·Microbes and Infection·Julia A Schwartzman, Edward G Ruby
Jul 5, 2011·Zoology : Analysis of Complex Systems, ZACS·Elizabeth A C Heath-Heckman, Margaret J McFall-Ngai
Feb 7, 2009·Environmental Microbiology·Spencer V NyholmMargaret J McFall-Ngai
Jun 29, 2015·Fish & Shellfish Immunology·Maria G CastilloNina R Joffe
Jul 19, 2008·The Journal of Biological Chemistry·Clelia De-la-PeñaJorge M Vivanco
Apr 20, 2018·Medical Sciences : Open Access Journal·Amjad A KhanArshad H Rahmani
Jan 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mahdi BelcaidSpencer V Nyholm
Oct 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Eric J KochMargaret McFall-Ngai
Feb 13, 2010·Cold Spring Harbor Protocols·Patricia N LeeH Gert de Couet

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