A personal journey of discovery: developing technology and changing biology

Annual Review of Analytical Chemistry
L Hood

Abstract

This autobiographical article describes my experiences in developing chemically based, biological technologies for deciphering biological information: DNA, RNA, proteins, interactions, and networks. The instruments developed include protein and DNA sequencers and synthesizers, as well as ink-jet technology for synthesizing DNA chips. Diverse new strategies for doing biology also arose from novel applications of these instruments. The functioning of these instruments can be integrated to generate powerful new approaches to cloning and characterizing genes from a small amount of protein sequence or to using gene sequences to synthesize peptide fragments so as to characterize various properties of the proteins. I also discuss the five paradigm changes in which I have participated: the development and integration of biological instrumentation; the human genome project; cross-disciplinary biology; systems biology; and predictive, personalized, preventive, and participatory (P4) medicine. Finally, I discuss the origins, the philosophy, some accomplishments, and the future trajectories of the Institute for Systems Biology.

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A GoldsteinL Hood
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M Maxam, W Gilbert
May 25, 1975·Journal of Molecular Biology·F Sanger, A R Coulson
Aug 1, 1975·Analytical Biochemistry·J Silver, L Hood
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H ShizuyaM Simon
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I MononenJ Groffen
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D A NickersonU Landegren
May 15, 1990·Analytical Biochemistry·R AebersoldL E Hood
Aug 11, 1989·Nucleic Acids Research·R J KaiserL E Hood
Sep 29, 1989·Science·M OlsonD Botstein
Apr 1, 1985·Cell·B OeschL E Hood
Apr 1, 1986·Analytical Biochemistry·E C StraussL E Hood
Sep 16, 1988·Science·G PárragaR E Klevit
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I Clark-LewisS B Kent
Aug 26, 1988·Science·U LandegrenL Hood
Jan 1, 1987·Methods in Enzymology·S J HorvathL Hood
Jun 12, 1986·Nature·L M SmithL E Hood
Apr 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·L E HoodW J Dreyer
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A V SchallyL E Hood
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A GoldsteinL Hood
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E HellerF Strumwasser
Feb 1, 1980·Science·M W Hunkapiller, L E Hood
Jun 27, 1980·Science·M A RafteryL E Hood
Nov 15, 1994·Analytical Biochemistry·G M HuangL Hood
Mar 20, 1995·Analytical Biochemistry·K WangL Hood
May 30, 1996·Nature·J C VenterL Hood
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·M SuzukiL A Loeb
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·A Y LiuG van den Engh

❮ Previous
Next ❯

Citations

Feb 21, 2009·Functional & Integrative Genomics·R Appels
Jul 10, 2012·Modern Rheumatology·Hisashi YamanakaShigeki Momohara
Jun 2, 2009·Biomedical Instrumentation & Technology·Chad E Kennedy
Jul 18, 2014·Genome Medicine·Anna Pokorska-BocciHilary Burton
Jan 29, 2016·Medicine, Health Care, and Philosophy·Henrik VogtLinn Getz
Jul 24, 2012·Advanced Drug Delivery Reviews·Miroslaw JanowskiPiotr Walczak
Dec 15, 2015·Microbiome·Carine Gimbert, François-Joseph Lapointe
Aug 6, 2009·EMBO Reports·Jane Calvert, Joan H Fujimura
May 20, 2014·Biochimica Et Biophysica Acta·Marten H HofkerCisca Wijmenga
Apr 14, 2011·Studies in History and Philosophy of Biological and Biomedical Sciences·Jane Calvert, Joan H Fujimura
Jun 16, 2016·Autoimmunity Reviews·Juan-Manuel AnayaAdriana Rojas-Villarraga
Mar 12, 2010·Natural Product Research·Nighat Sultana, Asaad Khalid
May 29, 2018·British Journal of Health Psychology·Stacey Oliver, Eva Kemps
Oct 2, 2019·Cold Spring Harbor Perspectives in Medicine·Erica Ramos
Mar 1, 2014·Personalized Medicine·Anna Pokorska-BocciHilary Burton
May 30, 2020·The Proceedings of the Nutrition Society·J Bernadette Moore
Sep 16, 2011·Clinical Neurosurgery·Paul Porensky, E Antonio Chiocca
Jan 6, 2010·Angewandte Chemie·He WangZheng Ouyang
Mar 29, 2019·Emerging Topics in Life Sciences·Laura A TsengClara D M van Karnebeek
Mar 28, 2012·ACS Nano·Paul S Weiss

❮ Previous
Next ❯

Methods Mentioned

BETA
protein folding
electrophoresis
chips
enzymatic oligonucleotide ligation
DNA array
chip
DNA array technology
surface plasmon resonance

Software Mentioned

ABI
Sequest
ISB
Cytoscape

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Journal of Proteome Research
Thomas E Fehniger, György Marko-Varga
Proceedings of the National Academy of Sciences of the United States of America
Qihui ShiJames R Heath
Scientific American
James R HeathLeroy Hood
© 2021 Meta ULC. All rights reserved