A Perspective on Candidate Neural Underpinnings of Binge Eating Disorder: Reward and Homeostatic Systems

Current Pharmaceutical Design
Amelia RomeiAntonio Verdejo-Garcia

Abstract

People with Binge Eating Disorder (BED) exhibit heightened sensitivity to rewarding stimuli and elevated activity in reward-related brain regions, including the orbitofrontal cortex (OFC), ventral striatum (VS) and insula, during food-cue exposure. BED has also been associated with altered patterns of functional connectivity during resting-state. Investigating neural connectivity in the absence of task stimuli provides knowledge about baseline communication patterns that may influence the behavioural and cognitive manifestation of BED. Elevated resting-state functional connectivity (rsFC) between reward-related brain regions may contribute to uncontrolled eating bouts observed in BED, through heightened food-cue sensitivity and food-craving. The impact of homeostatic state on rsFC of the reward system has not yet been investigated in people with BED. Homeostatic dysfunction is a key driver of excessive food consumption in obesity, whereby rsFC between rewardrelated brain regions does not attenuate during satiety. Future studies should investigate BED related differences in rsFC within the reward system during hunger and satiety, in order to determine whether individuals with BED display an abnormal neural response to changes in...Continue Reading

References

Dec 15, 1990·The Journal of Comparative Neurology·D S Zahm, L Heimer
May 22, 1998·Archives of General Psychiatry·C G FairburnM E O'Connor
Aug 4, 1999·Brain : a Journal of Neurology·S RahmanT W Robbins
Jul 13, 2000·Archives of General Psychiatry·C G FairburnM O'Connor
Aug 28, 2001·Brain : a Journal of Neurology·D M SmallM Jones-Gotman
Oct 18, 2002·Neuron·Clifford B SaperJoel K Elmquist
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Aug 6, 2003·The International Journal of Eating Disorders·Cynthia M Bulik, Ted Reichborn-Kjennerud
Sep 18, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Elke StephanRobert L Goodale
Nov 19, 2003·The European Journal of Neuroscience·Ivan E T de AraujoNicola Phillips
Jan 20, 2004·Nature Neuroscience·Hugo D CritchleyRaymond J Dolan
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ivan E De Araujo, Edmund T Rolls
May 12, 2004·Brain and Cognition·Edmund T Rolls
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·Sharon Dawe, Natalie J Loxton
Jan 4, 2005·NeuroImage·Paul A M SmeetsJeroen van der Grond
Jan 18, 2005·NeuroImage·Cornelia KrancziochAndreas K Engel
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Mar 8, 2006·Archives of General Psychiatry·James I HudsonHarrison G Pope
Jun 17, 2006·Annual Review of Neuroscience·Marcus E Raichle, Mark A Mintun
Jul 4, 2006·Biological Psychiatry·James I HudsonRonald C Kessler
Dec 8, 2006·The American Journal of Psychiatry·Harrison G PopeJames I Hudson
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Apr 10, 2007·Annual Review of Neuroscience·Jonathan D Wallis
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean B Ostlund, Bernard W Balleine
Nov 11, 2008·Biological Psychiatry·Anne SchienleDieter Vaitl
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Jan 24, 2009·Current Opinion in Pharmacology·Kent C BerridgeJ Wayne Aldridge
Feb 3, 2009·Obesity·Deborah L Reas, Carlos M Grilo
Feb 25, 2009·The International Journal of Eating Disorders·Tracey D WadeNicholas G Martin
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcus E Raichle
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric SticeDana M Small
May 11, 2012·The American Journal of Clinical Nutrition·Sabine FrankRalf Veit

❮ Previous
Next ❯

Citations

Jun 20, 2020·Current Pharmaceutical Design·Maria Carmen Blanco-Gandía, Marta Rodríguez-Arias

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Postgraduate Medicine
C Brendan MontanoBarry K Herman
The Psychiatric Clinics of North America
Anna I GuerdjikovaSusan L McElroy
The Medical Clinics of North America
Anna I GuerdjikovaSusan L McElroy
© 2021 Meta ULC. All rights reserved