A Perspective on Cell Therapy and Cancer Vaccine in Biliary Tract Cancers (BTCs)

Cancers
Shuting HanHan Chong Toh

Abstract

Biliary tract cancer (BTC) is a rare, but aggressive, disease that comprises of gallbladder carcinoma, intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, with heterogeneous molecular profiles. Advanced disease has limited therapeutic options beyond first-line platinum-based chemotherapy. Immunotherapy has emerged as a viable option for many cancers with a similar unmet need. Therefore, we reviewed current understanding of the tumor immune microenvironment and recent advances in cellular immunotherapy and therapeutic cancer vaccines against BTC. We illustrated the efficacy of dendritic cell vaccination in one patient with advanced, chemorefractory, melanoma-associated antigen (MAGE)-positive gallbladder carcinoma, who was given multiple injections of an allogenic MAGE antigen-positive melanoma cell lysate (MCL)-based autologous dendritic cell vaccine combined with sequential anti-angiogenic therapy. This resulted in good radiological and tumor marker response and an overall survival of 3 years from diagnosis. We postulate the potential synergism of adding anti-angiogenic therapy, such as bevacizumab, to immunotherapy in BTC, as a rational scientific principle to positively modulate the tumor microenvironment to...Continue Reading

References

Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoJ Folkman
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Tadlock, T Patel
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hajime IsomotoGregory J Gores
Aug 1, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G RandiC La Vecchia
Sep 6, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·S A KhanS D Taylor-Robinson
Oct 28, 2009·World Journal of Gastroenterology : WJG·Hans-Udo KasperAnton Gillessen
Dec 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Han Chong TohMogens H Claesson
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sam J LubnerKyle D Holen
Sep 8, 2010·The New England Journal of Medicine·Philip W KantoffUNKNOWN IMPACT Study Investigators
Feb 8, 2011·Current Opinion in Gastroenterology·Alphonse E SiricaCatherine I Dumur
Mar 8, 2011·American Journal of Clinical Oncology·Soo-Fan AngSu-Pin Choo
Jan 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kimberly NoonanIvan Borrello
Mar 13, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Atsushi ArugaMasakazu Yamamoto
Jul 24, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Masanori KobayashiUNKNOWN DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT)
Oct 19, 2013·British Journal of Cancer·B GoeppertW Weichert
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Mar 13, 2014·Journal of Translational Medicine·Atsushi ArugaMasakazu Yamamoto
May 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Anchalee TechasenPuangrat Yongvanit
Feb 19, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel A GoldsteinChristopher R Flowers
Aug 11, 2015·Nature Genetics·Hiromi NakamuraTatsuhiro Shibata
Nov 26, 2015·World Journal of Gastrointestinal Oncology·Eric I Marks, Nelson S Yee
Feb 24, 2017·Visceral Medicine·Martha M Kirstein, Arndt Vogel
Aug 19, 2017·Cancer Discovery·Juan W ValleAndrew X Zhu
Nov 18, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Loic VerlingueAntoine Hollebecque
Feb 22, 2018·The New England Journal of Medicine·Alexander DrilonDavid M Hyman
Mar 7, 2018·Trends in Cancer·Dan HøgdallJesper B Andersen
Mar 24, 2018·European Journal of Haematology·Marzia PalmaHåkan Mellstedt
Mar 31, 2018·Cancer Immunology, Immunotherapy : CII·Daniel Rojas-SepúlvedaFlavio Salazar-Onfray
Mar 26, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Luca FabrisMario Strazzabosco
Jun 4, 2019·Frontiers in Immunology·Rodrigo Barbosa de Aguiar, Jane Zveiter de Moraes

❮ Previous
Next ❯

Citations

Feb 12, 2021·Expert Review of Gastroenterology & Hepatology·Alessandro Rizzo, Giovanni Brandi
Feb 17, 2021·Cancer Treatment and Research Communications·Alessandro Rizzo, Giovanni Brandi
Jul 1, 2021·Immunotherapy·Nikolaos CharalampakisDimitrios Schizas

❮ Previous
Next ❯

Methods Mentioned

BETA
exome sequencing
flow cytometry

Software Mentioned

ClarIDHy

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yi Chai
Journal of Hepato-biliary-pancreatic Sciences
Margaret SutherlandShahid Ahmed
Current Treatment Options in Oncology
Urvi A ShahLakshmi Rajdev
© 2021 Meta ULC. All rights reserved