A perspective on the next generation of antibacterial agents derived by manipulation of natural products

Progress in Medicinal Chemistry
Pamela Brown, Michael J Dawson

Abstract

Natural products have been a major source of anti-infective drugs for many decades. With urgent need for new antibacterial agents to combat drug-resistant bacteria, the investigation of both new and existing classes of natural products has once again become an important focus. In this review, we highlight how a medicinal chemistry/semi-synthetic approach to natural product manipulation continues to offer a valuable strategy to overcome limitations in current therapy. Approaches to address toxicity and to improve the solubility, bioavailability and the spectrum of activity are demonstrated. Examples are drawn from aminoglycosides, glycopeptides, tetracyclines, macrolides, thiazolyl peptides, pleuromutilins and polymyxins and are taken from the current literature, patents and abstracts of symposia. In many cases, this approach has led to drug candidates currently in late stages of clinical development.

Citations

May 25, 2018·Natural Product Research·Shasank S SwainRabindra N Padhy
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco Cen-PachecoJosé Javier Fernández
Jun 17, 2020·Chemistry : a European Journal·Klara AradiMaria Duca
Feb 26, 2019·Journal of Chemical Information and Modeling·Deyani Nocedo-MenaHumbert González-Díaz

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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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