A Perspective on the Use of NB-UVB Phototherapy vs. PUVA Photochemotherapy

Frontiers in Medicine
Sally H Ibbotson

Abstract

Narrowband UVB (NB-UVB) phototherapy and psoralen-UVA (PUVA) photochemotherapy are widely used phototherapeutic modalities for a range of skin diseases. The main indication for NB-UVB and PUVA therapies is psoriasis, and other key diagnoses include atopic eczema, vitiligo, cutaneous T-cell lymphoma (CTCL), and the photodermatoses. The decision on choice of phototherapy is important and NB-UVB is usually the primary choice. NB-UVB phototherapy is a safe and effective therapy which is usually considered when topical agents have failed. PUVA requires prior psoralen sensitization but remains a highly effective mainstay therapy, often used when NB-UVB fails, there is rapid relapse following NB-UVB or in specific indications, such as pustular or erythrodermic psoriasis. This review will provide a perspective on the main indications for use of NB-UVB and PUVA therapies and provide comparative information on these important dermatological treatments.

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Citations

Jul 26, 2019·Experimental Dermatology·Franz J Legat
Dec 31, 2019·Dermatologic Therapy·Kun ZhangLu Sun
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Mar 2, 2021·Frontiers in Cell and Developmental Biology·Vega Widya KarismaJulia Li Zhong
Nov 7, 2020·Photodiagnosis and Photodynamic Therapy·Monika NimbalkarS J Dhoble
May 8, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Abudujilili AbuduainiHaji Akbar Aisa
Feb 10, 2021·Photodermatology, Photoimmunology & Photomedicine·Rina KoizumiChikako Nishigori

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