A pH-responsive prodrug delivery system self-assembled from acid-labile doxorubicin-conjugated amphiphilic pH-sensitive block copolymers

Materials Science & Engineering. C, Materials for Biological Applications
Xiangxuan HuangCan Yang Zhang

Abstract

The development of intelligent drug delivery system that can efficiently deliver doxorubicin (DOX) to tumor site with controlled drug release performance and enhanced therapeutic efficacy is of great significance for cancer chemotherapy. In this report, a nano-prodrug system was prepared successfully by conjugating DOX to pH-sensitive amphiphilic diblock copolymer poly (ethylene glycol) methyl ether‑b‑poly (β‑amino esters) through acid-labile cis‑aconityl moiety (mPEG-b-PAE-cis-DOX). The resultant complex copolymer-drug was able to self-assemble into polymeric micelles (PMs) in an aqueous solution at low concentration, and the critical micelle concentration (CMC) was 3.6 mg/L which was increased as decrease of pH value. H-nuclear magnetic resonance (1H NMR), Fourier transform infrared (FT-IR), dynamic light scattering (DLS), transition electron microscopy (TEM), and classic acid-base titration were combined to confirm and characterize the chemical structure of the copolymer/drug conjugates and the physicochemical properties of the prodrug system. The DOX loading capacity, drug delivery and therapeutic efficacy of the conjugates were evaluated in vitro and in vivo. Notably, the antitumor experiments in tumor-bearing mice demonst...Continue Reading

Citations

Aug 9, 2019·Cancer Chemotherapy and Pharmacology·J DelahousseA Paci
Jul 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinping ShiCan Yang Zhang
Jun 5, 2020·International Journal of Nanomedicine·Yanhua JiangTe Fang
Dec 15, 2018·Advanced Healthcare Materials·Yong LiuLinqi Shi
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Jianhong LiaoQun Wang
Jul 3, 2020·Colloids and Surfaces. B, Biointerfaces·Qingqing PanBin He
Jul 30, 2021·Advanced Science·Yuezhou ZhangWei Huang
Jan 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Muhamad Alif RaziNoriho Kamiya

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