A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation

Drug Delivery
Helal Abdo MoqbelMohamed Ahmed El-Nabarawi

Abstract

Muscle spasm needs prompt relief of symptoms. Chlorzoxazone is a centrally muscle relaxant. The aim of this study was to prepare chlorzoxazone orodispersible tablets (ODTs) allowing the drug to directly enter the systemic circulation and bypassing the first-pass metabolism for both enhancing its bioavailability and exerting a rapid relief of muscular spasm. ODTs were prepared by direct compression method using Pharmaburst®500, Starlac®, Pearlitol flash®, Prosolv® odt and F-melt® as co-processed excipients. Three ratios of the drug to the other excipients were used (0.5:1, 1:1 and 2:1). All ODTs were within the pharmacopeial limits for weight and content. ODTs containing Pharmaburst®500 showed the shortest wetting time (∼45.33 s), disintegration time (DT) (∼43.33 s) and dissolution (Q15min 100.63%). By increasing the ratio of CLZ: Pharmaburst®500 from 0.5:1 to 1:1 and 2:1, the DT increased from 26.43 to 28.0 and 43.33 s, respectively. By using Prosolv® odt, ODTs failed to disintegrate in an acceptable time >180 s. DT of ODTs using different co-processed excipients can be arranged as follows: Pharmaburst® 500 < F-melt® <Pearlitol flash® <Starlac® <Prosolv® odt. Pharmacokinetic study of the optimum formula F1 (50 mg CLZ) in rabbit...Continue Reading

References

Dec 1, 1970·The Journal of Pharmacy and Pharmacology·A B Selkirk, D Ganderton
May 1, 1984·Journal of Pharmaceutical Sciences·P ColomboA La Manna
Jun 13, 1998·The Journal of Pharmacy and Pharmacology·H Seager
Feb 10, 2000·Journal of Computer Assisted Tomography·C H ParkC H Lee
Jun 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshio KunoHiroaki Nakagami
Nov 1, 2005·International Journal of Pharmaceutics·Takao MizumotoKatsuhide Terada
Jun 27, 2006·AAPS PharmSciTech·Omaima A SammourAhmed S Zidan
Dec 17, 2008·Recent Patents on Drug Delivery & Formulation·Honey GoelAshok K Tiwary
May 2, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Raguia Ali ShoukriRehab N Shamma
Jun 30, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·R P Dixit, S P Puthli
Feb 18, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·I Stoltenberg, J Breitkreutz
Aug 28, 2012·Current Drug Delivery·T NagarajuY Shravan Kumar
Feb 8, 2013·Expert Opinion on Drug Delivery·Ali Al-khattawi, Afzal R Mohammed

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Citations

Aug 19, 2016·Drug Development and Industrial Pharmacy·Helal Abdo MoqbelMohamed Ahmed El-Nabarawi
Nov 7, 2019·Drug Development and Industrial Pharmacy·Mohamed S MohamedAhmed M Samy
Mar 12, 2017·Drug Delivery and Translational Research·Mohamed Yousif MoutasimMohamed Ahmed El-Nabarawi
Nov 26, 2021·Expert Opinion on Drug Delivery·Raphael WiedeyJörg Breitkreutz

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