A pharmacodynamic model of respiratory rate and end-tidal carbon dioxide values during anesthesia in children.

Acta Pharmacologica Sinica
Ji-Hyun LeeHee-Soo Kim

Abstract

It is essential to monitor the end-tidal carbon dioxide (ETCO2) during general anesthesia and adjust the tidal volume and respiratory rate (RR). For the purpose of this study, we used a population pharmacodynamic modeling approach to establish the relationship between RR versus ETCO2 data during general anesthesia in children, and to identify the clinical variables affecting this relationship. A prospective observational study was designed to include 51 patients (aged ≤ 12 years), including users of antiepileptic drugs (levetiracetam, valproic, or phenobarbital (n = 21)) and non-users (n = 30), scheduled to receive general anesthesia during elective surgery. When the ETCO2 was at 40 mmHg, the RR was adjusted 1 breath per every 2 min until the ETCO2 was 30 mmHg and recovered to 40 mmHg. Pharmacodynamic analysis using a sigmoid Emax model was performed to assess the RR-ETCO2 relationship. As RR varied from 3 to 37 breaths per minute, the ETCO2 changed from 40 to 30 mmHg. Hysteresis between the RR and ETCO2 was observed and accounted for when the model was developed. The Ce50 (RR to achieve 50% of maximum decrease in ETCO2; i.e. 35 mmHg) was 20.5 in non-users of antiepileptic drugs and 14.9 in those on antiepileptic drug medicatio...Continue Reading

References

Jul 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K Bhavani-ShankarY Delph
Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Jul 19, 2011·Epilepsy & Behavior : E&B·Martin J BrodieH Steve White
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Céline BoiteuxToby W Allen
Aug 27, 2014·Clinics in Chest Medicine·Kristie R Ross, Carol L Rosen
Nov 12, 2014·The Journal of General Physiology·Karl F HeroldHugh C Hemmings
Apr 5, 2015·Expert Opinion on Therapeutic Targets·Antonio LeoEmilio Russo
Nov 7, 2015·Nature Reviews. Drug Discovery·Gerald W Zamponi
Aug 23, 2017·Advances in Neurobiology·Arne SchousboePovl Krogsgaard-Larsen
Nov 17, 2017·International Journal of Molecular Sciences·Paolo BazzigaluppiPeter L Carlen

❮ Previous
Next ❯

Software Mentioned

NONMEM
fit4NM
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Bridgette D GuthrieElizabeth C Powell
Archives of Disease in Childhood. Fetal and Neonatal Edition
Daragh FinnEugene M Dempsey
© 2022 Meta ULC. All rights reserved