A pharmacokinetic comparison of controlled-release and standard naproxen tablets

Current Medical Research and Opinion
N J Ryley, G Lingam

Abstract

The single-dose (750 mg) pharmacokinetics of controlled-release and standard naproxen tablets were compared in a randomized crossover study in 12 healthy male volunteers. Plasma samples collected over the 60 hours after drug administration were assayed for naproxen concentrations using high pressure liquid chromatography. The controlled-release formulation produced a significantly (p less than 0.001) lower and later mean peak naproxen concentration than the conventional-release tablets. However, no differences were observed in either area under the plasma concentration-time curve or elimination half-life. The two formulations were judged, therefore, to be bioequivalent based on the total amount of drug absorbed.

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Citations

Apr 21, 2005·Child: Care, Health and Development·P GiagazoglouN Angelopoulou
Mar 1, 2005·Public Health·H Perera
Apr 14, 2017·CNS Drugs·Peer Tfelt-HansenJacob Tfelt-Hansen

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