A pharmacokinetic interaction study of avitriptan and propranolol

Clinical Pharmacology and Therapeutics
P H MaratheR H Barbhaiya

Abstract

To assess whether a clinically significant change in the pharmacokinetics of avitriptan and propranolol is observed in healthy subjects after coadministration of the two drugs. The pharmacokinetics of avitriptan and propranolol were investigated when the two drugs administered separately and when two 150 mg doses of avitriptan 2 hours apart were added to a steady-state regimen (80 mg twice a day) of propranolol. The pharmacokinetics of metabolites of avitriptan (N-desmethylavitriptan, methoxypyrimidinyl piperazine, and O-desmethylavitriptan) and the pharmacokinetics of 4-hydroxypropranolol were also assessed. Administration of avitriptan alone and together with propranolol resulted in small increases in mean blood pressure and small decreases in heart rate. Administration of propranolol resulted in lowering of blood pressure and heart rate consistent with the beta-blocking actions of propranolol. There were no changes in the pharmacokinetics of avitriptan after coadministration with propranolol. However, area under the plasma concentration-time curve (AUC) of propranolol showed a 20% increase after coadministration with avitriptan, whereas the AUC of 4-hydroxypropranolol significantly decreased. Avitriptan therefore appeared to...Continue Reading

References

Jan 1, 1991·Journal of Neurology·P R Saxena, M O Den Boer
Nov 1, 1991·British Journal of Clinical Pharmacology·A K ScottP A Fowler
Jan 1, 1991·Journal of Cardiovascular Pharmacology·S T HallM Pellegatti
Nov 1, 1990·Journal of Pharmacobio-dynamics·M YasuharaC Kawai
Jan 1, 1989·Clinical Pharmacology and Therapeutics·S A WardR A Branch
Jun 1, 1988·Journal of Clinical Pharmacy and Therapeutics·M E Abdel-Hamid
Dec 1, 1981·British Journal of Clinical Pharmacology·N D BaxG T Tucker
Dec 1, 1984·Journal of Pharmacokinetics and Biopharmaceutics·C S Locke
Oct 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·S Riegelman, P Collier
Oct 1, 1980·Clinical Pharmacology and Therapeutics·K A Conrad, D W Nyman
Nov 11, 1993·The New England Journal of Medicine·K M Welch
Mar 1, 1993·Journal of Clinical Pharmacology·G D Solomon

❮ Previous
Next ❯

Citations

Apr 14, 2017·CNS Drugs·Peer Tfelt-HansenJacob Tfelt-Hansen
Apr 23, 2020·International Journal of Molecular Sciences·Barbora VyhlídalováZdenek Dvorak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.