PMID: 512846Aug 1, 1979Paper

A pharmacokinetic model to differentiate preabsorptive, gut epithelial, and hepatic first-pass metabolism

Journal of Pharmacokinetics and Biopharmaceutics
W A Colburn

Abstract

A combined perfusion/compartmental pharmacokinetic model has been developed to describe the time course of drugs that are subject to preabsorptive, intestinal epithelial, and hepatic first-pass metabolism. Equations are derived to estimate the fraction of the administered dose which is metabolized at each of the three sites and to establish the limits of the true absorption rate constant. The model is tested using literature data for phenacetin.

References

May 1, 1978·Journal of Pharmaceutical Sciences·D P Vaughan, M Dennis
Aug 1, 1977·Journal of Pharmaceutical Sciences·L I Harrison, M Gibaldi
Aug 1, 1971·Journal of Pharmaceutical Sciences·K B BischoffJ A Longstreth

Citations

Jan 1, 1990·Pharmacology & Therapeutics·K F IlettR F Minchin
Jun 6, 2000·Advanced Drug Delivery Reviews·D D ShenK E Thummel
Sep 1, 1985·Environmental Health Perspectives·J M Mayer, H van de Waterbeemd
Jan 9, 1998·Drug Metabolism Reviews·C L ZimmermanY K Pithavala
Jan 1, 1982·IEEE Transactions on Bio-medical Engineering·R F Brown
Aug 1, 1988·Journal of Clinical Pharmacology·W A Colburn
Dec 1, 2001·Biological & Pharmaceutical Bulletin·S UedaT Nakagawa
Mar 1, 1982·The Journal of Pharmacy and Pharmacology·K IwamotoJ Watanabe

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