A pharmacokinetic study of amoxycillin in febrile beagle dogs following repeated administrations of endotoxin

Journal of Veterinary Pharmacology and Therapeutics
J F MarierP Vachon

Abstract

The pharmacokinetics of amoxycillin was studied in nine male beagle dogs under healthy and febrile conditions. In Period 1, dogs received 20 mg/kg of an oral suspension of amoxycillin. Intravenous doses of saline, 2 and 20 microg/kg of endotoxin (LPS from Escherichia coli serotype) were administered to dogs (three per group) prior to administration of 20 mg/kg of amoxycillin in Period 2. Rectal temperature and behavioral changes were recorded and blood samples were collected over 12 h for pharmacokinetic analysis. Amoxycillin was assessed in plasma using liquid chromatography coupled with mass spectrometry. Plasma concentrations were analysed using a one-compartment model with lag-time for absorption using an iterative two-stage method. As compared with control groups, amoxycillin clearance decreased significantly with preliminary treatments of 2 microg/kg endotoxin (0.209 vs. 0.140 L/h kg, P < 0.05) and 20 microg/kg endotoxin (0.214 vs. 0.075 L/h kg, P < 0.05). As a result of this, the area under curve for the 2 and 20 microg/kg endotoxin groups increased significantly 100.4 vs. 149.4 microg h/mL (P < 0.05) and 99.2 vs. 277.7 microg h/mL (P < 0.05), respectively. Other drugs currently used for the treatment of fever and septic...Continue Reading

References

Apr 1, 1977·Journal of Pharmaceutical Sciences·P G WellingP O Madsen
Dec 1, 1977·The Journal of Small Animal Practice·A D Watson, J R Egerton
Apr 29, 1978·The Veterinary Record·M E FrancisW T Turner
Dec 11, 1976·The Veterinary Record·A S Van MiertJ G Wit
Apr 1, 1986·Antimicrobial Agents and Chemotherapy·F F HorberF C Reubi
Jan 1, 1986·European Journal of Drug Metabolism and Pharmacokinetics·J LavickýA Kubícek
Mar 20, 1971·Lancet·C H BeresfordO G Brooks
Mar 1, 1996·Infectious Disease Clinics of North America·A R Sarwari, P A Mackowiak
Aug 22, 2000·American Journal of Veterinary Research·H AgersøJ P Nielsen
Mar 1, 1950·The American Journal of Physiology·D BLICKENSTAFF, M I GROSSMAN

❮ Previous
Next ❯

Citations

Jun 19, 2007·Journal of the American Veterinary Medical Association·Rebecca J GreerF A Mann
May 20, 2008·Fundamental & Clinical Pharmacology·Audrey BoulameryBernard Bruguerolle
Sep 15, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M ElmasA Er Karabacak
Jul 19, 2006·Journal of Veterinary Pharmacology and Therapeutics·M Ismail
Dec 20, 2005·Veterinary Research Communications·M ElmasA Karabacak
Mar 1, 2020·Journal of Veterinary Pharmacology and Therapeutics·Saranya PoapolathepAmnart Poapolathep
Apr 13, 2011·Journal of Veterinary Pharmacology and Therapeutics·M RebueltoR Hallu
Jan 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Danuta Szkutnik-FiedlerEdmund Grześkowiak
Sep 13, 2013·Veterinary Dermatology·Katrine L VoieSidonie N Lavergne
Dec 7, 2021·Frontiers in Veterinary Science·Maria D Vegas CómitreLudovic Pelligand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved