PMID: 9004187Dec 1, 1996Paper

A pharmacokinetic study of sublingual aerosolized morphine in healthy volunteers

The Journal of Pharmacy and Pharmacology
N W WatsonO B Eden

Abstract

A pharmacokinetic study was undertaken to compare the pharmacokinetics of morphine after an intravenous dose with the pharmacokinetics after a sublingual dose administered from an aerosol. Plasma levels of morphine, morphine-3-glucuronide and morphine-6-glucuronide were measured in five normal volunteers after morphine administration by the intravenous route and from a novel sublingual pressurized aerosol formulation. The mean (+/- s.d.) bioavailability of the sublingual aerosol morphine was 19.7 +/- 6.7%. The morphine-3-glucuronide/morphine and the morphine-6-glucuronide/morphine ratios were 5.1 +/- 1.6 and 1.2 +/- 0.4, respectively, for the intravenous route and 28.3 +/- 11.3 and 5.2 +/- 1.4, respectively, for the sublingual route. The combined total areas under the plots of systemic concentration against time (AUC) for the metabolites after the two routes was not significantly different. When compared with published data for oral administration the results demonstrate that the sublingual aerosol morphine might provide an alternative to conventional methods of morphine delivery, and has similar pharmacokinetics to a sublingual morphine tablet. It has no particular pharmacokinetic advantages over oral morphine, except a potent...Continue Reading

References

Aug 1, 1992·British Journal of Clinical Pharmacology·R OsborneM Slevin
Jan 1, 1990·Life Sciences·M T SmithT Cramond
Nov 1, 1987·The Journal of Pharmacy and Pharmacology·O Al-Sayed-OmarP Turner
May 1, 1983·Journal of Pharmacological Methods·A Johnston, R C Woollard

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Citations

May 3, 2007·Journal of Palliative Medicine·Gary M Reisfield, George R Wilson
Jul 20, 2002·Clinical Pharmacokinetics·Hao ZhangJames B Streisand
Sep 1, 2012·AAPS PharmSciTech·Jeremy A Bartlett, Kees van der Voort Maarschalk
Apr 28, 2010·Expert Review of Neurotherapeutics·Mellar P Davis

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