PMID: 37543Apr 11, 1979

A pharmacologic study of analgesia produced by stimulation of the nucleus locus coeruleus

Psychopharmacology
D Margalit, M Segal

Abstract

Pharmacologic studies of analgesia produced by stimulation of the nucleus locus coeruleus (LC) were conducted using the rat hot-plate test. A correlation between self-stimulation and analgesia produced by stimulation of LC was found. Analgesia produced by LC stimulation was attenuated by naloxone, a morphine antagonist, cyproheptidine, a serotonin antagonist, and WB-4101, an alpha-adrenergic antagonist. The analgesia was absent in 6-OHDA-treated rats. Catecholamine synthesis inhibition by a combination of reserpine and AMT or more specific inhibition of noradrenaline synthesis by DDC elevated latency to paw lick and yet did not affect stimulation-produced analgesia. It is suggested that morphinergic, serotonergic, and alpha-adrenergic mechanisms mediate LC stimulation produced analgesia.

References

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Feb 13, 1976·Brain Research·M Segal
Aug 29, 1975·Brain Research·H Akil, J C Liebeskind
Dec 1, 1976·Pain·D J Mayer, D D Price
Apr 30, 1976·Brain Research·E T PierceJ A Hobson
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Related Concepts

Adrenergic alpha-Antagonists
Ditiocarb, Tin(4+) Salt
Hydroxydopamine
Structure of Locus Ceruleus
Viternum
V-Serp
Self Stimulation
Isoglaucon
Prozac
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer

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