PMID: 7538137Feb 1, 1995Paper

A pharmacological analysis of calcium channels involved in phasic and tonic responses of the guinea-pig ureter to high potassium

Journal of Autonomic Pharmacology
C A Maggi, S Giuliani

Abstract

1. Previous studies have established a marked difference in sensitivity to organic calcium channel blockers of the phasic compared with tonic component of the contraction to potassium chloride (KCl) in the guinea-pig ureter. The mechanisms responsible for this difference have remained unsettled. In particular, the possible involvement of non-L-type calcium channels in contractility of the ureter has not been determined. In this study we have re-addressed this problem and, to eliminate any possible contribution of sensory neuropeptides released by KCl from peripheral endings of afferent nerves, all experiments were performed in ureters pre-exposed to the sensory neurone blocking agent, capsaicin (10 microM for 15 min). 2. Increasing concentrations of KCl (10-160 mM) produced phasic and tonic contractions of the guinea-pig isolated ureter: the L-type calcium channel agonist, Bay K 8644 (1 microM), enhanced both components of the contraction to KCl. 3. Nifedipine (1 microM) abolished all responses to increasing concentrations of KCl after 60 min contact time; after a shorter incubation period (15 min), the phasic contractions to low KCl concentrations were still observed, while the tonic responses were abolished. 4. The effects of...Continue Reading

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Citations

Jan 21, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Jasmin Katrin BadawiStephan Bross
May 7, 2004·Peptides·Astor Grumann JúniorJoão B Calixto
Feb 6, 2014·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Kyle D WoodJorge Gutierrez
Jan 28, 2014·Pflügers Archiv : European journal of physiology·C H Fry, R I Jabr
Nov 27, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X CarpentierC Saussine
Oct 3, 2006·Lancet·Margaret S Pearle
Oct 3, 2006·Lancet·John M HollingsworthBrent K Hollenbeck
Sep 9, 2010·PLoS Genetics·Sébastien SénatoreNathalie Lalevée
Mar 31, 2017·Drugs·Tarik AmerOmar Aboumarzouk

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