A pharmacological analysis of the hyperactivity syndrome induced by beta-phenylethylamine in the mouse

British Journal of Pharmacology
C T Dourish

Abstract

1 The effects of the putative 5-hydroxytryptamine (5-HT) receptor antagonists, methysergide, mianserin and methergoline, the dopamine receptor antagonists, haloperidol, thioridazine and clozapine, and the noradrenaline (NA) receptor antagonists, phentolamine, phenoxybenzamine and propranolol on the behavioural responses of mice to beta-phenylethylamine (PEA, 75 mg/kg) have been examined.2 PEA produced a syndrome consisting of three distinct phases. The brief initial phase (0-5 min after injection) which consisted of forward walking, sniffing and headweaving, was succeeded by a locomotor depressant phase (5-20 min after injection) which consisted of abortive grooming, headweaving, splayed hindlimbs, forepaw padding, sniffing and hyperreactivity, and a late locomotor stimulant phase (20-35 min after injection), which was characterized by forward walking, sniffing, hyperreactivity, rearing and licking.3 Methysergide, mianserin, methergoline, clozapine and propranolol inhibited headweaving and splayed hindlimbs, whereas haloperidol, thioridazine, phentolamine and phenoxybenzamine had no effect on these responses. Forepaw padding was strongly inhibited by methergoline and a high dose of mianserin, and weakly antagonized by methyserg...Continue Reading

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Citations

Feb 22, 1996·European Journal of Pharmacology·N Barroso, M Rodriguez
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·S J Cooper, C T Dourish
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·C L Kutscher
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·E Head, N W Milgram
Dec 1, 1982·Psychiatry Research·C T Dourish, A A Boulton
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·P S McQuade, P L Wood
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·C T Dourish, S J Cooper
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·C T Dourish
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Dec 12, 1995·Brain Research·M Rodriguez, N Barroso
Nov 19, 2011·Annals of the New York Academy of Sciences·F Ivy CarrollP Anantha Reddy

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