A pharmacological and biochemical examination of the geographical variation of Chironex fleckeri venom

Toxicology Letters
Kelly L WinterWayne C Hodgson

Abstract

Chironex fleckeri (box jellyfish) are found in the northern tropical waters of Australia. Although C. fleckeri have a wide geographical distribution and are able to swim large distances, adults tend to stay in small restricted areas. Clinical data shows that deaths from envenoming have not been recorded in Western Australia, yet numerous fatalities have occurred in Northern Territory and Queensland waters. One explanation for this discrepancy is a geographical variation in venom composition. This study examined the pharmacological and biochemical profiles of C. fleckeri venom from different geographical locations and seasons. Venoms were screened for cytotoxicity using a rat aortic smooth muscle cell line (A7r5). While all venoms caused concentration-dependent cytotoxicity, differences were seen in the potency of venoms from Mission Beach and Weipa, when collected in different seasons, as indicated by IC(50) values. Similarly venoms collected within the same season, from different locations around Australia, displayed marked differences in venom composition as shown by size exclusion HPLC and SDS-PAGE profiles which indicated the absence or reduced quantity of 'peaks' in some venoms. Based on IC(50) data obtained from the cell ...Continue Reading

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Citations

Feb 11, 2014·Toxicon : Official Journal of the International Society on Toxinology·Beilei WangLiming Zhang
Aug 28, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Athena AndreossoJamie E Seymour
Oct 7, 2014·Toxicon : Official Journal of the International Society on Toxinology·Sophie Badré
Feb 26, 2013·Marine Drugs·Luca CegolonGiuseppe Mastrangelo
Sep 20, 2015·Toxicon : Official Journal of the International Society on Toxinology·Dalia PonceJuan José Dorantes-Aranda
Nov 16, 2012·Toxicon : Official Journal of the International Society on Toxinology·Beilei WangLiming Zhang
Apr 15, 2016·Marine Drugs·Bárbara Frazão, Agostinho Antunes
May 9, 2012·Toxicon : Official Journal of the International Society on Toxinology·Silvia L A Saggiomo, Jamie E Seymour
Sep 27, 2012·Toxicon : Official Journal of the International Society on Toxinology·S McClounan, J Seymour
Nov 9, 2016·Toxicon : Official Journal of the International Society on Toxinology·Yang YuePengcheng Li
Dec 22, 2019·Toxins·Nezahat Pınar BarkanAntoine Guisan
Dec 31, 2019·PloS One·Muhamad Rusdi Ahmad RusmiliJaneyuth Chaisakul
Mar 31, 2017·The Medical Journal of Australia·Jamie E Seymour
Mar 21, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Mongkon CharoenpitakchaiJaneyuth Chaisakul
Oct 31, 2020·International Journal of Biological Macromolecules·Chunlin YuPengcheng Li
Jun 19, 2021·Toxicon: X·E P O'HaraJ E Seymour

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