A pharmacological evidence of positive association between mouse intermale aggression and brain serotonin metabolism

Behavioural Brain Research
Alexander V KulikovNina K Popova

Abstract

The neurotransmitter serotonin (5-HT) is involved in the regulation of mouse intermale aggression. Previously, it was shown that intensity of mouse intermale aggression was positively associated with activity of the key enzyme of 5-HT synthesis - tryptophan hydroxylase 2 (TPH2) in mouse brain. The aim of the present study was to investigate the effect of pharmacological activation or inhibition of 5-HT synthesis in the brain on intermale aggression in two mouse strains differing in the TPH2 activity: C57BL/6J (B6, high TPH2 activity, high aggressiveness) and CC57BR/Mv (BR, low TPH2 activity, low aggressiveness). Administration of 5-HT precursor L-tryptophan (300 mg/kg, i.p.) to BR mice significantly increased the 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels in the midbrain as well as the number of attacks and their duration in the resident-intruder test. And vice versa, administration of TPH2 inhibitor p-chlorophenylalanine (pCPA) (300 mg/kg, i.p., for 3 consecutive days) to B6 mice dramatically reduced the 5-HT and 5-HIAA contents in brain structures and attenuated the frequency and the duration of aggressive attacks. At the same time, L-tryptophan or pCPA did not influence the percentage of aggressive mice and the atta...Continue Reading

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Citations

Oct 7, 2014·Pharmacology, Biochemistry, and Behavior·Magda NowickiRobert Gerlai
Mar 27, 2015·Clinical Genetics·E E PalmerM Field
Jul 15, 2015·Reviews in the Neurosciences·Alexander V Kulikov, Nina K Popova
Aug 13, 2013·Behavioural Brain Research·Pablo JuárezCraig H Kennedy
Mar 16, 2018·Expert Opinion on Therapeutic Targets·Alexander V KulikovNina K Popova
Jan 22, 2019·Expert Opinion on Therapeutic Targets·Nina K Popova, V S Naumenko
Jun 20, 2019·Expert Opinion on Therapeutic Targets·Elizabeth A Kulikova, Alexander V Kulikov

Related Concepts

Tph2 protein, mouse
Aggressive Behavior
Brain
Electrochemistry
Enzyme Inhibitors
Curiosity
Hydroxyindoleacetic Acid
Mice, Inbred BALB C
Mice, Inbred C57BL
Fenclonine, (D)-Isomer

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