The study of taste has been guided throughout much of its history by the conceptual framework of psychophysics, where the focus was on quantification of the subjective experience of the taste sensations. By the mid-20th century, data from physiologic studies had accumulated sufficiently to assemble a model for the function of receptors that must mediate the initial stimulus of tastant molecules in contact with the tongue. But the study of taste as a receptor-mediated event did not gain momentum until decades later when the actual receptor proteins and attendant signaling mechanisms were identified and localized to the highly specialized taste-responsive cells of the tongue. With those discoveries a new opportunity to examine taste as a function of receptor activity has come into focus. Pharmacology is the science designed specifically for the experimental interrogation and quantitative characterization of receptor function at all levels of inquiry from molecules to behavior. This review covers the history of some of the major concepts that have shaped thinking and experimental approaches to taste, the seminal discoveries that have led to elucidation of receptors for taste, and how applying principles of receptor pharmacology ca...Continue Reading
Biochemical studies of taste sensation--VIII. Partial characterization of alanine-binding taste receptor sites of catfish Ictalurus punctatus using mercurials, sulfhydryl reagents, trypsin and phospholipase C
Biochemical studies of taste sensation: binding to taste tissue of 3H-labeled monellin, a sweet-tasting protein
Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction
An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation
Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography
Sodium chloride detection threshold in the rat determined using a simple operant taste discrimination task
Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
Site-directed mutagenesis of the histamine H1 receptor: roles of aspartic acid107, asparagine198 and threonine194
Characteristics of action potentials and their underlying outward currents in rat taste receptor cells
Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat
Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems
Identification of two alpha-subunit species of GTP-binding proteins, Galpha15 and Galphaq, expressed in rat taste buds
Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium
Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception
Covariation in individuals' sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms
Relationship of papillae number to bitter intensity of quinine and PROP within and between individuals
Fast and accurate measurement of taste and smell thresholds using a maximum-likelihood adaptive staircase procedure
Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine
Monosodium glutamate and sweet taste: generalization of conditioned taste aversion between glutamate and sweet stimuli in rats
Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathway
A paracrine signaling role for serotonin in rat taste buds: expression and localization of serotonin receptor subtypes
Glutamate taste: Discrimination between the tastes of glutamate agonists and monosodium glutamate in rats
Are three-sample tasks less sensitive than two-sample tasks? Memory effects in the testing of taste discrimination
Monosodium glutamate and sweet taste: discrimination between the tastes of sweet stimuli and glutamate in rats
The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3
From small sweeteners to sweet proteins: anatomy of the binding sites of the human T1R2_T1R3 receptor
The relationship between phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) taster status and taste thresholds for sucrose and quinine
Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25
The mode of action of nicotine and curari, determined by the form of the contraction curve and the method of temperature coefficients
Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin
Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice
Development of a universal high-throughput calcium assay for G-protein- coupled receptors with promiscuous G-protein Galpha15/16
Quantitative assessment of TRPM5-dependent oral aversiveness of pharmaceuticals using a mouse brief-access taste aversion assay
Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice
The relationship between fungiform papillae density and detection threshold for sucrose in the young males
Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners detected by saturation transfer difference NMR spectroscopy
Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds
Cell-to-cell communication in intact taste buds through ATP signalling from pannexin 1 gap junction hemichannels
Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay
Obese women have lower monosodium glutamate taste sensitivity and prefer higher concentrations than do normal-weight women
Sugar content of popular sweetened beverages based on objective laboratory analysis: focus on fructose content
Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel
Evaluation of the Monell forced-choice, paired-comparison tracking procedure for determining sweet taste preferences across the lifespan
The cysteine-rich domain of human T1R3 is necessary for the interaction between human T1R2-T1R3 sweet receptors and a sweet-tasting protein, thaumatin
One hundred years since the discovery of the "umami" taste from seaweed broth by Kikunae Ikeda, who transcended his time
Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin
Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) mice
Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds
The ATP permeability of pannexin 1 channels in a heterologous system and in mammalian taste cells is dispensable
Sensory-specific appetition: Postingestive detection of glucose rapidly promotes continued consumption of a recently encountered flavor
Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31
Extensive lesions in the gustatory cortex in the rat do not disrupt the retention of a presurgically conditioned taste aversion and do not impair unconditioned concentration-dependent licking of sucrose and quinine
Determination of aristolochic acids by high-performance liquid chromatography with fluorescence detection
L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors
Extensive Gustatory Cortex Lesions Significantly Impair Taste Sensitivity to KCl and Quinine but Not to Sucrose in Rats
Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios
Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications
Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans.
CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes
Critically evaluating sweet taste receptor expression and signaling through a molecular pharmacology lens.
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