A pharmacological profile of ribavirin and monitoring of its plasma concentration in chronic hepatitis C infection

Journal of Clinical and Experimental Hepatology
Girish S Naik, Manoj G Tyagi

Abstract

Chronic hepatitis C (CHC) infection, usually an asymptomatic infection, has long-term serious complications such as cirrhosis, hepatocellular carcinoma, and end-stage liver disease requiring liver transplantation (LT). Several novel drugs against hepatitis C which form part of 'specifically targeted antiviral therapy for hepatitis C' (STAT-C) have been developed. These include NS3/4A protease inhibitors telaprevir, boceprevir, and nucleoside/non-nucleoside polymerase inhibitors (NS5A) which hold promise for future therapy. Despite the development of new anti-hepatitis C virus (HCV) drugs, ribavirin (RBV) remains the single most important drug to prevent relapse and is frequently included among newer regimens being developed with novel small molecule anti-HCV drugs. The current approved treatment is a combination therapy of once weekly subcutaneous pegylated-interferon (PEG-IFN)-α plus body-weight-based oral RBV regimen. The most significant dose-dependent side effect of RBV is hemolytic anemia warranting dose reduction or discontinuation in severe cases compromising sustained virological response (SVR). Monitoring RBV plasma concentration has been challenging due to its peculiar pharmacokinetics and has been done to predict bot...Continue Reading

Citations

Aug 26, 2020·Human & Experimental Toxicology·Ahmed A ElnfarawyRehab S Abdelrahman
Sep 6, 2020·Pharmacological Reports : PR·Thakur Uttam SinghRaj Kumar Singh
Dec 20, 2016·Scientific Reports·Rahul Shubhra MandalSantasabuj Das
Jun 9, 2015·Frontiers in Microbiology·Jun-Da ZhuHwa-Chain R Wang
Jun 23, 2021·Analytical Methods : Advancing Methods and Applications·Mingyan SongZhouping Wang

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