A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer.

International Journal of Radiation Oncology, Biology, Physics
Yasmin HasanMichael Spiotto

Abstract

This study assessed the safety and tolerability of therapeutic immunization against the human papillomavirus (HPV) viral oncoproteins E6 and E7 in patients with cervical cancer after chemoradiation. MEDI0457 (INO-3112) is a DNA-based vaccine targeting E6 and E7 of HPV-16/18 that is coinjected with an IL-12 plasmid followed by electroporation with the CELLECTRA 5P device. At 2 to 4 weeks after chemoradiation, patients with newly diagnosed stage IB1-IVA (cohort 1) or persistent/recurrent (cohort 2) cervical cancers were treated with 4 immunizations of MEDI0457 every 4 weeks. The primary endpoints were incidence of adverse events and injection site reactions. Immune responses against HPV antigens were measured by ELISpot for interferon-γ (IFNγ), enzyme-linked immunosorbent assay for antibody responses and multiplexed immunofluorescence for immune cells in cervical biopsy specimens. Ten patients (cohort 1, n = 7; cohort 2, n = 3) with HPV16 (n = 7) or HPV18 (n = 3) cervical cancers received MEDI0457 after chemoradiation. Treatment-related adverse events were all grade 1, primarily related to the injection site. Eight of 10 patients had detectable cellular or humoral immune responses against HPV antigens after chemoradiation and vac...Continue Reading

References

Oct 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W C GrayJ V Ordonez
Aug 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M ChattergoonD B Weiner
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Jul 16, 2003·International Immunopharmacology·Emma L VerasteguiJohn Hadden
Apr 8, 2004·Vaccine·Michael A ChattergoonDavid B Weiner
Dec 14, 2004·American Journal of Obstetrics and Gynecology·Yutaka NagaiKoji Kanazawa
Jan 11, 2007·The Journal of Experimental Medicine·Bin ZhangHans Schreiber
Nov 6, 2009·The New England Journal of Medicine·Gemma G KenterCornelis J M Melief
Mar 27, 2010·International Journal of Radiation Oncology, Biology, Physics·Alessandra BattagliaAndrea Fattorossi
Nov 11, 2010·International Journal of Cancer. Journal International Du Cancer·Yong Jung SongSang-Yoon Park
Feb 3, 2011·American Journal of Obstetrics and Gynecology·Jean-Luc BrunJean-Paul Bory
Oct 12, 2012·Science Translational Medicine·Mark L BagarazziNiranjan Y Sardesai
Dec 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jarrod PredinaSunil Singhal
Apr 27, 2013·Lancet·Emma J CrosbieHenry C Kitchener
Jul 19, 2014·International Journal of Radiation Oncology, Biology, Physics·Chad TangJames W Welsh
Dec 10, 2014·Expert Review of Vaccines·Kate E Broderick, Laurent M Humeau
Sep 27, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Liam MastersonJane Sterling
Nov 23, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew E SpectorFrancis P Worden
Jan 6, 2017·Molecular Therapy Oncolytics·Matthew P MorrowMark L Bagarazzi
Apr 8, 2017·Cancer Biomarkers : Section a of Disease Markers·Glenn J HannaJonathan D Schoenfeld
Sep 21, 2017·Nature Communications·N JacquelotL Zitvogel
Jan 11, 2018·Human Gene Therapy·Max A ChengT-C Wu
Feb 16, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Malte MohmeKatrin Lamszus
Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Elisa PeranzoniEmmanuel Donnadieu
Jun 15, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ariel E MarciscanoCharles G Drake
Sep 23, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charu AggarwalMark L Bagarazzi

❮ Previous
Next ❯

Citations

Aug 15, 2020·Frontiers in Immunology·Lea Skak Filtenborg FrederiksenAneesh Thakur
Apr 27, 2021·Expert Opinion on Drug Safety·Sarah K CiminoCathy Eng
Aug 25, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Neerja BhatlaLalit Kumar
Apr 24, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Louise FerrallT-C Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Control : Journal of the Moffitt Cancer Center
J V Fiorica
Gan to kagaku ryoho. Cancer & chemotherapy
Takafumi ToitaSadayuki Murayama
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Peter G Rose, Brian N Bundy
© 2021 Meta ULC. All rights reserved