A phase 2 study of rituximab, bendamustine, bortezomib and dexamethasone for first-line treatment of older patients with mantle cell lymphoma

Haematologica
Rémy GressinLymphoma Study Association

Abstract

We present results of a prospective, multicenter, phase II study evaluating rituximab, bendamustine, bortezomib and dexamethasone as first-line treatment for patients with mantle cell lymphoma aged 65 years or older. A total of 74 patients were enrolled (median age, 73 years). Patients received a maximum of six cycles of treatment at 28-day intervals. The primary objective was to achieve an 18-month progression-free survival rate of 65% or higher. Secondary objectives were to evaluate toxicity and the prognostic impact of mantle cell lymphoma prognostic index, Ki67 expression, [18F]fluorodeoxyglucose-positron emission tomography and molecular minimal residual disease, in peripheral blood or bone marrow. With a median follow-up of 52 months, the 24-month progression-free survival rate was 70%, hence the primary objective was reached. After six cycles of treatment, 91% (54/59) of responding patients were analyzed for peripheral blood residual disease and 87% of these (47/54) were negative. Four-year overall survival rates of the patients who did not have or had detectable molecular residual disease in the blood at completion of treatment were 86.6% and 28.6%, respectively (P<0.0001). Neither the mantle cell lymphoma index, nor fl...Continue Reading

Citations

Aug 3, 2019·Expert Opinion on Pharmacotherapy·Piotr SmolewskiTadeusz Robak
Apr 26, 2019·Leukemia & Lymphoma·Tadeusz RobakMartin Dreyling
Apr 10, 2019·American Journal of Hematology·Preetesh Jain, Michael Wang
May 6, 2020·Drugs & Aging·Jason T Romancik, Jonathon B Cohen
Apr 18, 2019·Drugs in R&D·Pawel Robak, Tadeusz Robak
Sep 19, 2020·Expert Opinion on Drug Safety·Anna Korycka-WołowiecTadeusz Robak
Apr 28, 2020·Leukemia & Lymphoma·Jia RuanPeter Martin
Oct 20, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Preetesh JainMichael Wang
Mar 13, 2021·Expert Opinion on Pharmacotherapy·Farheen ManjiDouglas A Stewart
Aug 31, 2020·Hematology/oncology Clinics of North America·Jia Ruan
Aug 31, 2020·Hematology/oncology Clinics of North America·Marco LadettoChristiane Pott
Aug 27, 2019·La Presse médicale·Clémentine Sarkozy, Gilles Salles
Nov 20, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Preetesh JainMichael L Wang

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Methods Mentioned

BETA
biopsies
biopsy
flow cytometry

Clinical Trials Mentioned

NCT01457144

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