A Phase 2 Trial of Concurrent Chemotherapy and Proton Therapy for Stage III Non-Small Cell Lung Cancer: Results and Reflections Following Early Closure of a Single-Institution Study

International Journal of Radiation Oncology, Biology, Physics
Bradford S HoppeRomaine C Nichols

Abstract

Proton therapy has been shown to reduce radiation dose to organs at risk (OAR) and could be used to safely escalate the radiation dose. We analyzed outcomes in a group of phase 2 study patients treated with dose-escalated proton therapy with concurrent chemotherapy for stage 3 non-small cell lung cancer (NSCLC). From 2009 through 2013, LU02, a phase 2 trial of proton therapy delivering 74 to 80 Gy at 2 Gy/fraction with concurrent chemotherapy for stage 3 NSCLC, was opened to accrual at our institution. Due to slow accrual and competing trials, the study was closed after just 14 patients (stage IIIA, 9 patients; stage IIIB, 5 patients) were accrued over 4 years. During that same time period, 55 additional stage III patients were treated with high-dose proton therapy, including 7 in multi-institutional proton clinical trials, 4 not enrolled due to physician preference, and 44 who were ineligible based on strict entry criteria. An unknown number of patients were ineligible for enrollment due to insurance coverage issues and thus were treated with photon radiation. Median follow-up of surviving patients was 52 months. Two-year overall survival and progression-free survival rates were 57% and 25%, respectively. Median lengths of ove...Continue Reading

References

Mar 4, 1999·AJR. American Journal of Roentgenology·D A BushJ M Slater
Nov 13, 1999·Chest·D A BushJ M Slater
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Yoshiyuki ShioyamaKiyohisa Sekizawa
Oct 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Hidetsugu NakayamaKoichi Tokuuye
Sep 10, 2011·Journal of the National Cancer Institute·Walter J CurranJames D Cox
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfram BruggerFederico Cappuzzo
Dec 14, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yoshiko OshiroHideyuki Sakurai
Jan 24, 2012·Clinical Lung Cancer·Bradford S HoppeR Charles Nichols
Jan 31, 2012·International Journal of Radiation Oncology, Biology, Physics·James D Cox
Jul 4, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michaela A DinanMorris Weinberger
May 28, 2014·Journal of Radiation Research·Yoshiko OshiroHideyuki Sakurai
Jun 20, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardenalC Faivre-Finn

❮ Previous
Next ❯

Citations

Mar 2, 2017·World Journal of Clinical Oncology·Stephanie M YoonMark Hallman
Jul 18, 2018·Therapeutic Advances in Respiratory Disease·Melissa A L VyfhuisCharles B Simone
Apr 1, 2018·International Journal of Particle Therapy·Vivek VermaCharles B Simone
Oct 30, 2020·Expert Review of Anticancer Therapy·Nirav V PatelPranshu Mohindra
Aug 6, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L De MarziM Vidal
Aug 17, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·S-L WongR Mendes
Jan 10, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stanislav LazarevCharles B Simone
Feb 22, 2021·Seminars in Radiation Oncology·Caitlin A SchonewolfRobert T Dess
Jun 24, 2021·Journal of Applied Clinical Medical Physics·Jingjing M DoughertyYevgeniy Vinogradskiy
Jun 28, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyung Su Kim, Hong-Gyun Wu
Jun 16, 2021·Cold Spring Harbor Perspectives in Medicine·Michael DohopolskiPuneeth Iyengar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.