Abstract
A prospective, single-arm, open-label, nonrandomized Phase 2 study of combined fludarabine and mitoxantrone (FM) plus radioimmunotherapy was conducted to evaluate efficacy and safety in patients with untreated, indolent, nonfollicular non-Hodgkin lymphoma (NHL). Between February 2005 and June 2006, at their institute, the authors treated 26 eligible patients with previously untreated, indolent, nonfollicular NHL (10 marginal zone lymphomas, 8 lymphoplasmacytic lymphomas, and 8 small lymphocytic lymphomas) using a novel regimen that consisted of 6 cycles of FM chemotherapy followed 6 to 10 weeks later by yttrium-90 (90Y) ibritumomab tiuxetan. After FM chemotherapy, the overall response rate was 80.5% and included a 50% complete remission (CR) rate (13 patients) and a 30.5% partial remission (PR) rate (8 patients). Of the 20 patients (13 with CR and 7 with PR) who were evaluable (at least a PR with normal platelet counts and bone marrow infiltration <25%) for subsequent 90Y ibritumomab tiuxetan, 100% obtained a CR at the end of the entire treatment regimen. At a median follow-up of 20 months, the estimated 3-year progression-free survival rate was 89.5%, and the estimated 3-year overall survival rate was 100%. The 90Y ibritumomab...Continue Reading
References
May 11, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R RedmanM J Keating
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S HochsterM J O'Connell
Dec 6, 1984·The New England Journal of Medicine·S J Horning, S A Rosenberg
Oct 1, 1995·European Journal of Haematology·P L ZinzaniS Tura
Sep 4, 1993·Lancet·A C WotherspoonP G Isaacson
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P McLaughlinM Keating
Aug 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P L ZinzaniR Fanin
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P McLaughlinF Cabanillas
Apr 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P L ZinzaniS Tura
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N R SchechterJ Yahalom
Mar 17, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LazzarinoC Bernasconi
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T E WitzigA J Grillo-López
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N L HarrisC D Bloomfield
Jan 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M ForanT A Lister
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P L ZinzaniS Tura
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S HochsterP A Cassileth
May 16, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P L ZinzaniS Tura
Mar 17, 2001·Statistics in Medicine·R P A'Hern
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigChristine A White
May 31, 2002·Blood·Gregory A WisemanChristine A White
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigChristine A White
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John D HainsworthUNKNOWN Minnie Pearl Cancer Research Network
May 26, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pier Luigi ZinzaniMichele Baccarani
Jun 30, 2004·Leukemia & Lymphoma·Pier Luigi ZinzaniMichele Baccarani
Jul 31, 2004·Blood·Roswitha ForstpointnerUNKNOWN German Low-Grade Lymphoma Study Group
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John P LeonardStanley J Goldsmith
Aug 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Oliver W PressUNKNOWN Southwest Oncology Group
Sep 2, 2006·Blood·Roswitha ForstpointnerUNKNOWN German Low Grade Lymphoma Study Group (GLSG)
Citations
Feb 22, 2011·Annals of Hematology·Eun Ji HanSeok-Goo Cho
Mar 18, 2008·The Lancet Oncology·Pier Luigi ZinzaniMichele Baccarani
Mar 2, 2011·Cancer Biotherapy & Radiopharmaceuticals·Robert O Dillman
Nov 7, 2008·Nuclear Medicine Communications·Sergio Lo MeoMario Marengo
Feb 3, 2009·Blood·Robert M SharkeyDavid M Goldenberg
Aug 24, 2012·Cancer Cell International·Jiangning ZhaoQuanyi Lu
Jan 1, 2009·Cancer Management and Research·Christos Emmanouilides
Mar 15, 2011·Immunotherapy·Robert M Sharkey, David M Goldenberg
Jul 7, 2012·Japanese Journal of Radiology·Makoto NakagawaSatoru Uehara
Apr 27, 2012·Advances in Hematology·Kenneth A FoonPier L Zinzani
Mar 12, 2013·International Journal of Hematologic Oncology·Qiushi ChenChristopher R Flowers
May 19, 2010·Journal of Cancer Research and Therapeutics·Mourad AribiKaoual Meguenni
Jun 6, 2014·Nuclear Medicine and Molecular Imaging·Geon Wook KangSang Moo Lim
Aug 17, 2011·Current Oncology Reports·Eileen M Boyle, Franck Morschhauser
May 18, 2010·Leukemia & Lymphoma·Sairah AhmedAndrew M Evens
Jul 29, 2008·Leukemia & Lymphoma·Frederic PeyradeAntoine Thyss
Mar 28, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tadeusz RobakPawel Robak
Jun 16, 2009·Clinical Lymphoma & Myeloma·John D HainsworthF Anthony Greco
Jan 23, 2010·American Journal of Hematology·Umberto VitoloSante Tura
Feb 4, 2010·Cancer·Robert M SharkeyDavid M Goldenberg
May 23, 2015·Nature Reviews. Cancer·Steven M LarsonOliver W Press
Sep 2, 2014·Clinical Lymphoma, Myeloma & Leukemia·Andrew C Cannon, Fausto R Loberiza
Jun 3, 2014·Therapeutic Advances in Hematology·Antonio C Sánchez RuizMariano Provencio Pulla
Jun 26, 2010·Bone Marrow Transplantation·A D'AddioR M Lemoli
Apr 4, 2019·Leukemia & Lymphoma·Marc SorigueJuan-Manuel Sancho
Oct 21, 2009·The Oncologist·Franck MorschhauserAngelika Bischof Delaloye
Aug 18, 2017·Medicine·Xiaoping ZhangChong Gao
Aug 1, 2020·The Cancer Journal·Francesco BertoniEmanuele Zucca
Jun 20, 2012·Cancer Control : Journal of the Moffitt Cancer Center·Michael Tomblyn
Aug 7, 2020·Leukemia & Lymphoma·Izidore S LossosJuan Pablo Alderuccio
Dec 5, 2020·Hematology·Alessandro Broccoli, Pier Luigi Zinzani
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anand VeeravaguXiaoyuan Chen
Apr 22, 2017·Cancer Research·Damian J Green, Oliver W Press
Oct 20, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Angelika Bischof DelaloyeAnton Hagenbeek
May 31, 2021·Leukemia Research·Esha ShardaRahul Mhaskar