A phase I single-blind clinical trial to evaluate the safety of oil palm phenolics (OPP) supplementation in healthy volunteers

Scientific Reports
Syed FairusRavigadevi Sambanthamurthi

Abstract

Plant phenolics are being increasingly consumed globally with limited scientific and clinical evidence pertaining to safety and efficacy. The oil palm fruit contains a cocktail of phenolics, and palm oil production results in high volumes of aqueous by-products enriched in phenolics and bioactives. Several lines of evidence from in vitro and in vivo animal studies confirmed that the aqueous extract enriched in phenolics and other bioactives collectively known as oil palm phenolics (OPP) is safe and has potent bioactivity. A phase one clinical trial was conducted to evaluate the safety and effects of OPP in healthy volunteers. In this single-blind trial, 25 healthy human volunteers were supplemented with 450 mg gallic acid equivalent (GAE)/day of OPP or control treatments for a 60-day period. Fasting blood and urine samples were collected at days 1, 30 and 60. Medical examination was performed during these trial interventions. All clinical biochemistry profiles observed throughout the control and OPP treatment period were in the normal range with no major adverse effect (AE) or serious adverse effect (SAE) observed. Additionally, OPP supplementation resulted in improvement of total cholesterol and LDL-C levels, compared to the c...Continue Reading

References

Dec 20, 1999·Journal of Agricultural and Food Chemistry·Q Y ZhuZ Y Chen
Oct 23, 2002·ILAR Journal·Ralph B DellRajasekhar Ramakrishnan
May 27, 2003·Diabetes Care·Kazuaki HosodaShigeru Yamamoto
Jan 11, 2005·The American Journal of Clinical Nutrition·Claudine ManachChristian Rémésy
Sep 24, 2005·The Journal of Nutrition·Tosca L Zern, Maria Luz Fernandez
Jan 6, 2006·Journal of Nutritional Science and Vitaminology·Yoko FukinoHiroyasu Iso
Sep 8, 2007·The American Journal of Clinical Nutrition·Fausta NatellaCristina Scaccini
Jul 30, 2008·Critical Reviews in Food Science and Nutrition·M S Fernandez-PanchonM C Garcia-Parrilla
Aug 13, 2010·The Journal of Nutrition·Linda A J van MierloRichard Draijer
Oct 20, 2010·The British Journal of Nutrition·Mary F-F ChongJulie A Lovegrove
Jul 9, 2011·The British Journal of Nutrition·Ravigadevi SambanthamurthiMohd Basri Wahid
Jul 9, 2011·The British Journal of Nutrition·Ravigadevi SambanthamurthiMohd Basri Wahid
Aug 26, 2011·BMC Genomics·Soon-Sen LeowRavigadevi Sambanthamurthi
Apr 25, 2012·European Journal of Nutrition·Soon-Sen LeowRavigadevi Sambanthamurthi
Jun 20, 2012·Journal of the Academy of Nutrition and Dietetics·Martin de BockWayne S Cutfield

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection

Software Mentioned

SPSS®
Statistical Package for Social Sciences ( SPSS® )
MS Excel
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The British Journal of Nutrition
Ravigadevi SambanthamurthiMohd Basri Wahid
The British Journal of Nutrition
Ravigadevi SambanthamurthiMohd Basri Wahid
Progress in Lipid Research
Ravigadevi SambanthamurthiY Tan
© 2022 Meta ULC. All rights reserved