A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers

Journal of Nutritional Science and Vitaminology
Egilius L H SpieringsThomas Walshe

Abstract

Active Hexose Correlated Compound (AHCC) is an extract of Lentinula edodes of the basidiomycete family of fungi rich in alpha glucans. AHCC has been used for many years as a dietary supplement to enhance the immune system and in clinical trials as an adjunctive treatment in Hepatocellular cancer. This multiple dose, Phase I trial, using FDA guidelines, directly investigates the clinical safety and tolerability of AHCC in healthy subjects. Its safety has been based previously on anecdotal reports and its use in clinical practice. Twenty-six healthy male or female subjects between the ages of 18 and 61 were recruited from the community and gave their consent to participate in the trial. The subjects were given 9 g of AHCC (150 mL of the currently available liquid AHCC) PO daily for 14 d. Laboratory data was obtained at baseline and after 14 d of exposure to AHCC and adverse events were monitored by a non-directed review of systems questionnaire three times during the trial. At each visit the vital signs and adverse events were recorded. Two subjects (7%) dropped out because of nausea and intolerance of the liquid. Adverse effects of nausea, diarrhea, bloating, headache, fatigue, and foot cramps occurred in a total of 6 subjects (...Continue Reading

References

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Oct 19, 2002·Urology·Ralph W deVere WhiteBuxiang Sun

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Citations

Jul 9, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Sho HangaiTakuhiro Yamaguchi
Apr 14, 2015·Journal of Gastroenterology and Hepatology·Kazuyuki NarimatsuRyota Hokari
Oct 19, 2010·Regulatory Toxicology and Pharmacology : RTP·H FujiiA Roberts
Jun 2, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Shinil K ShahRichard J Andrassy
May 23, 2013·The Journal of Trauma and Acute Care Surgery·Katie M LoveWilliam G Cheadle
Jan 1, 2014·Journal of Nutritional Science and Vitaminology·Hyangkyoung KimJee-Aee Im
Nov 26, 2021·Drug Discovery Today·Sujogya Kumar Panda, Walter Luyten

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