A phase I trial of neutron brachytherapy for the treatment of malignant gliomas

The British Journal of Radiology
R A PatchellB Young

Abstract

We performed a phase I trial to test the feasibility of neutron brachytherapy using californium-252 (252Cf) as the sole source of radiation, and to determine the maximum tolerable dose (MTD), for the treatment of malignant gliomas. Previous studies using external beam neutron radiation have shown that neutrons are capable of totally eradicating malignant gliomas. However, in most cases, fatal widespread radiation necrosis resulted. Radioactive implants are a logical method of increasing the dose to the tumour and decreasing the dose to normal brain. 252Cf is a relatively stable neutron-emitting isotope suitable for implant therapy. The study was an open ended dose-escalation study. All radiation was delivered by using only 252Cf implants, without external beam therapy of any type. The first dose step was 900 neutron cGy (ncGy); each subsequent step was increased by 100 ncGy. Three patients with newly diagnosed malignant gliomas were entered at each dose step, and the number was increased to six patients in dose steps at which necrosis of brain occurred. The study ended when two patients at any dose step developed radiation necrosis of brain outside the prescribed radiation field. 33 patients were entered into the study. 10 pati...Continue Reading

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Citations

Jun 28, 2011·Radiation Protection Dosimetry·Sâmia F Brandão, Tarcísio P R Campos
Apr 3, 2015·Biology of Reproduction·Joanna Piasecka-SraderBrian K Petroff
Jan 31, 2019·Cardiovascular Research·Mary BarberJoe-Elie Salem
Mar 20, 1999·Current Opinion in Pediatrics·J B Rubin, M W Kieran
Nov 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Viviane Aline Oliveira SilvaRui Manuel Reis
Jun 4, 2005·Journal of Neuro-oncology·Todd W VitazPhilip H Gutin

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