A Phase I Trial of Temsirolimus and Pemetrexed in Patients with Advanced Non-Small Cell Lung Cancer

Chemotherapy
Saiama N WaqarRamaswamy Govindan

Abstract

Pemetrexed is an antifolate chemotherapeutic agent approved for use in non-small cell lung cancer (NSCLC). The mammalian target of rapamycin (mTOR) pathway is implicated in lung cancer development and inhibited by temsirolimus. We performed a phase I study evaluating the combination of pemetrexed and temsirolimus in advanced non-squamous NSCLC. Eight patients were enrolled in this study. The dose-limiting toxicities included grade 4 thrombocytopenia, grade 3 leukopenia and grade 3 neutropenia. The maximum tolerated dose was determined to be pemetrexed 375 mg/m2 intravenously on day 1 and temsirolimus 25 mg intravenously on days 1, 8 and 15. No objective responses were noted and 3 patients had stable disease as the best response. The combination of pemetrexed and temsirolimus is feasible and well tolerated. This combination may be further evaluated in patients with mTOR pathway activation, particularly in those with TSC1 or STK11 mutations.

Citations

Sep 26, 2020·Therapeutic Advances in Medical Oncology·Zachary D CreesNeelu Puri
Jun 8, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Panpan LvWenyuan Gao
Jul 20, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry· IksenVarisa Pongrakhananon

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