PMID: 9547676Jan 1, 1997Paper

A phase I trial of weekly gemcitabine administered as a prolonged infusion in patients with pancreatic cancer and other solid tumors

Investigational New Drugs
R BrandMargaret Tempero

Abstract

Pharmacological studies of gemcitabine (2',2'-difluorodeoxycytidine) have shown that increased levels of the active triphosphate metabolite are achieved by prolonging infusion time while holding the dose rate constant. The primary aim of this study was to determine the maximum tolerated dose (MTD) of gemcitabine administered as a fixed rate infusion (10 mg/m2/min) on a weekly schedule in patients with untreated non-hematologic malignancies. Twenty-seven patients (21 pancreatic adenocarcinoma, 3 hepatoma, 1 neuroendocrine tumor, and 2 adenocarcinoma of unknown primary) were enrolled in this open-label, non-randomized study. Three different entry dose levels (1200 mg/m2, 1500 mg/m2 and 1800 mg/m2) were evaluated for gemcitabine administered on days 1, 8, and 15 of a 28-day cycle. The MTD was defined as 1500 mg/m2 with granulocytopenia and thrombocytopenia being dose-limiting. There were no non-hematological dose limiting toxicities. The maximum WHO grade 3 or 4 toxicities for hemoglobin, leukocytes, neutrophils, and platelets for all doses of gemcitabine administered were 11.5%, 30.8%, 57.7%, and 26.9%, respectively. Non-hematologic toxicities included nausea, vomiting and fever. Four patients were withdrawn from the study for no...Continue Reading

Citations

Mar 4, 2005·Investigational New Drugs·Peter SchmidKurt Possinger
Mar 11, 2006·Cancer Chemotherapy and Pharmacology·G GossUNKNOWN Investigational New Drug Program of the National Cancer Institute of Canada Clinical Trials Group
Jul 20, 2007·Journal of Separation Science·Christian LanzBernhard H Lauterburg
Jul 31, 2007·Cancer Investigation·Benedito A CarneiroGershon Y Locker
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Varsha GandhiElihu H Estey
Dec 4, 2004·American Journal of Clinical Oncology·Cathy EngHedy L Kindler
May 17, 2006·Angiology·Fadi M BdairMilind M Javle
Feb 18, 2009·Cancer Chemotherapy and Pharmacology·Archie N TseNancy Kemeny
Aug 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S R PatelR S Benjamin
Apr 4, 2003·Cancer·Eric J SmallUNKNOWN Cancer and Leukemia Group B
Nov 24, 2005·Japanese Journal of Clinical Oncology·Junji FuruseMasahiro Yoshino
Mar 21, 2008·Cancer Chemotherapy and Pharmacology·Virginia FerraresiFrancesco Cognetti
Oct 31, 2012·Indian Journal of Cancer·M Zwitter
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Margaret TemperoJames Abbruzzese
Mar 11, 2009·Clinical Pharmacokinetics·Alessandra FeliciFrancesco Cognetti
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul SabbatiniDavid Spriggs
Oct 17, 2020·Clinical Pharmacokinetics·Ellen J B Derissen, Jos H Beijnen
Nov 7, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P M FracassoS L Sun
Mar 4, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sally AraiSandra J Horning
Feb 22, 2012·Gastroenterology Clinics of North America·David PáezHeinz-Josef Lenz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Varsha GandhiElihu H Estey
Annals of Oncology : Official Journal of the European Society for Medical Oncology
N TouroutoglouJ Abbruzzese
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
David A RizzieriJoseph O Moore
© 2022 Meta ULC. All rights reserved