A phase II evaluation of docetaxel and carboplatin followed by tumor volume directed pelvic plus or minus paraaortic irradiation for stage III endometrial cancer

Gynecologic Oncology
Dennis R ScribnerMichael A Gold

Abstract

To determine the feasibility and efficacy of administering docetaxel and carboplatin chemotherapy followed by tumor directed radiation in patients with advance stage endometrial cancer. Patients with surgical stage III or IV (confined to the pelvis) endometrial cancer were eligible. Treatment consisted of six cycles of docetaxel (75 mg/m(2)) and carboplatin (AUC 6) followed by irradiation to the involved field (50.4 Gy pelvis ± 43.5 Gy paraaortic)±brachytherapy. Kaplan-Meier (KM) methods estimated overall survival (OS) and progression free survival (PFS). Forty-five patients were enrolled, 34 (76.0%) completed the prescribed therapy. Median age 63.5 (35-85 years). Stage IIIA 8 (17.8%), IIIB 1 (2.2%) and IIIC 36 (80.0%). 39/45 (86.7%) had endometroid histology. Serious grade 4 toxicities included 14 non-hematologic and 2 hematologic. Sixteen patients died following treatment, 6 from recurrent progressive cancer, with a median follow-up of 35.6 months (0.4-74.8). KM estimates and standard error (SE) for OS at 1 year were 84.5%, (5.4%), at 3 years, 65.8%, (7.2%) and at 5 years, 56.7%, (7.9%). Median overall survival was 74.5 months. Fourteen patients recurred with KM estimates and standard error (SE) for PFS at 1 year 77.8%, (6.2%...Continue Reading

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Citations

Apr 11, 2014·Expert Opinion on Investigational Drugs·Stephanie LheureuxHelen J Mackay
Mar 18, 2015·Annals of Surgical Oncology·Andrea PapadiaFrancesco Raspagliesi
Jan 18, 2014·Gynecologic Oncology·Jamie N Bakkum-GamezKarl C Podratz
Apr 20, 2016·Gynecologic Oncology·Talha ShaikhPenny R Anderson
May 17, 2019·Journal of Cachexia, Sarcopenia and Muscle·Jie LeeYu-Jen Chen
Apr 29, 2016·Molecular and Clinical Oncology·Hiroyuki YoshidaKeiichi Fujiwara
Mar 28, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Deepa Maheswari NarasimhuluGretchen Glaser

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