A phase II exercise randomized controlled trial for patients with acute myeloid leukemia undergoing induction chemotherapy

Leukemia Research
Shabbir M H AlibhaiS Nicole Culos-Reed

Abstract

Curative treatment for acute myeloid leukemia (AML) involves induction chemotherapy (IC) which is associated with bed rest and toxicities, leading to worsening quality of life (QOL), fatigue, and fitness. Exercise during IC may ameliorate declines but has not been rigorously tested. We examined the efficacy of supervised exercise during IC on QOL, fatigue, and fitness. Eighty-three inpatients age 18-80 scheduled to receive IC for newly diagnosed or relapsed AML were randomized 2:1 (exercise intervention:control group). Study measures were completed at baseline, post-IC, and following the first cycle of consolidation. The intervention consisted of a supervised mixed-modality, moderate-intensity exercise program (4-5 days per week, 30-60min per session) throughout admission. Recruitment was good (56%), retention excellent (96%), and adherence was 54%. Global QOL improved similarly in both groups from baseline to post-IC (between-group difference 3.0 points, p=0.62). Fatigue improved in the exercise group from baseline to post-IC (potentially clinically important between-group difference of 3.6 points, p=0.23). Aerobic fitness, lower body strength, and grip strength improved in the exercise group (between-group differences p=0.005...Continue Reading

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Citations

Nov 21, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Neha KayasthaThomas W LeBlanc
Feb 1, 2019·The Cochrane Database of Systematic Reviews·Linus KnipsNicole Skoetz
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Oct 27, 2021·Journal of Research in Health Sciences·Masumeh Maleki BehzadHassan Rafieemehr

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