Abstract
Curative treatment for acute myeloid leukemia (AML) involves induction chemotherapy (IC) which is associated with bed rest and toxicities, leading to worsening quality of life (QOL), fatigue, and fitness. Exercise during IC may ameliorate declines but has not been rigorously tested. We examined the efficacy of supervised exercise during IC on QOL, fatigue, and fitness. Eighty-three inpatients age 18-80 scheduled to receive IC for newly diagnosed or relapsed AML were randomized 2:1 (exercise intervention:control group). Study measures were completed at baseline, post-IC, and following the first cycle of consolidation. The intervention consisted of a supervised mixed-modality, moderate-intensity exercise program (4-5 days per week, 30-60min per session) throughout admission. Recruitment was good (56%), retention excellent (96%), and adherence was 54%. Global QOL improved similarly in both groups from baseline to post-IC (between-group difference 3.0 points, p=0.62). Fatigue improved in the exercise group from baseline to post-IC (potentially clinically important between-group difference of 3.6 points, p=0.23). Aerobic fitness, lower body strength, and grip strength improved in the exercise group (between-group differences p=0.005...Continue Reading
References
Jun 1, 1992·Chest·R C BoneW J Sibbald
Mar 3, 1993·Journal of the National Cancer Institute·N K AaronsonJ C de Haes
Feb 1, 1997·Journal of Pain and Symptom Management·S B YellenE Kaplan
Apr 29, 1998·Leukemia·A SchumacherJ van de Loo
Jan 29, 2003·Journal of Pain and Symptom Management·David CellaDouglas E Merkel
Feb 11, 2003·Chest·Paul L EnrightUNKNOWN Cardiovascular Health Study
Feb 1, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vicki S ConnPaul J Nielsen
May 16, 2006·Journal of the American Geriatrics Society·J David CurbRandi Chen
Feb 9, 2007·Leukemia·S M H AlibhaiM D Minden
Sep 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C M SchneiderR Hayward
Nov 14, 2007·Journal of Clinical Epidemiology·George F BormWim A J G Lemmens
Feb 16, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lene ThorsenSophie D Fosså
Feb 19, 2008·Journal of Pain and Symptom Management·Pi-Hua ChangSue-Yueh Cheng
Nov 14, 2008·Cancer Treatment Reviews·Roberto D K S LiuWillem van Mechelen
Aug 15, 2009·Integrative Cancer Therapies·Claudio L BattagliniThomas Shea
Jun 19, 2010·Medicine and Science in Sports and Exercise·Kathryn H SchmitzUNKNOWN American College of Sports Medicine
Jun 26, 2012·Leukemia Research·Shabbir M H AlibhaiS Nicole Culos-Reed
Jun 26, 2012·Leukemia Research·H MohamedaliS M H Alibhai
Apr 4, 2013·Blood·Heidi D KlepinBayard L Powell
Jan 1, 2011·Journal of Geriatric Oncology·Heidi D KlepinShannon L Mihalko
Citations
Jul 28, 2016·PloS One·Yuan ZhouXiangguang Yin
Sep 29, 2017·British Journal of Sports Medicine·Maike G SweegersLaurien M Buffart
Nov 21, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Neha KayasthaThomas W LeBlanc
Oct 13, 2018·European Journal of Cancer Care·Takuya FukushimaMinoru Okita
Mar 23, 2018·Current Medical Research and Opinion·Jaein SeoJohn F P Bridges
Feb 1, 2019·The Cochrane Database of Systematic Reviews·Linus KnipsNicole Skoetz
Sep 6, 2018·British Journal of Sports Medicine·Maike G SweegersLaurien M Buffart
Apr 30, 2019·Scandinavian Journal of Medicine & Science in Sports·Ann Christin Helgesen BjørkeSveinung Berntsen
Dec 7, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Leonardo Barbosa de AlmeidaDaniel Godoy Martinez
Aug 23, 2016·The Cochrane Database of Systematic Reviews·Michael DesboroughMichael F Murphy
Aug 16, 2017·Annals of Hematology·Osai SamadiShabbir M H Alibhai
Oct 23, 2018·European Journal of Cancer Care·Karin PiilKathrine Hoffmann Pii
Jan 5, 2019·BMC Cancer·Shabbir M H AlibhaiNicole Culos-Reed
Nov 30, 2019·Current Hematologic Malignancy Reports·Kah Poh LohHeidi D Klepin
Aug 20, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Anja WehrleHartmut Bertz
Dec 6, 2019·Blood·Rebecca L Olin
Nov 28, 2020·Integrative Cancer Therapies·Monica DentiStefania Fugazzaro
Jul 23, 2020·Blood·Mohammed SaadHeidi D Klepin
Jun 24, 2021·British Journal of Haematology·Dominic O'ConnorGillian Prue
Oct 27, 2021·Journal of Research in Health Sciences·Masumeh Maleki BehzadHassan Rafieemehr
Nov 7, 2021·BMC Cancer·Kelcey A BlandKristin L Campbell