A phase II pharmacodynamic study of preoperative figitumumab in patients with localized prostate cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Kim N ChiMichael Pollak

Abstract

Activation of the insulin-like growth factor 1 receptor (IGF-IR) is implicated in prostate cancer development and progression. This study evaluated biologic and clinical effects of figitumumab, a fully human monoclonal IGF-IR antibody, in patients with localized prostate cancer. Eligible patients received figitumumab 20 mg/kg intravenously every 3 weeks for 3 cycles followed by prostatectomy. The primary endpoint was IGF-IR expression inhibition as assessed by immunohistochemistry. Sixteen patients were accrued. Median age was 63 years, median prostate-specific antigen (PSA) was 7.2 μg/L (range, 2.5-35), clinical stage was T1 in four patients and T2 in 12 patients, Gleason score ≤ 7 or >7 in 15 and one patients. Two patients received only 1 cycle (patient choice and grade III hyperglycemia). A PSA decline from baseline of ≥ 25% and ≥ 50% occurred in 15 (94%) and 5 (31%) of patients. Mean figitumumab concentration was 350.4 μg/mL (range, 26.3-492.8) in plasma and 51.3 μg/g (range, 27.4-79.6) in prostate tissue. Compared with pretreatment biopsies, IGF-IR expression decreased in the prostatectomy specimens in 14 of 16 patients. The mean IGF-IR immunohistochemistry visual score was 2.1 (SD = 0.6) in biopsy and 1.1 (SD = 0.5) in pr...Continue Reading

References

Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·J DiGiovanniC Conti
Jul 11, 2001·Urology·M F O'BrienJ M Fitzpatrick
Jul 18, 2002·Journal of the National Cancer Institute·June M ChanEdward Giovannucci
Sep 25, 2003·Human Pathology·Abderrahman OubanDomenico Coppola
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bruce D CohenJames D Moyer
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer D WuStephen R Plymate
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul HaluskaJohann S de Bono
Nov 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen R PlymateJennifer D Wu
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martha Q LacyAntonio Gualberto
Nov 26, 2008·Nature Reviews. Cancer·Michael Pollak
Apr 20, 2010·Lancet·Howard I ScherUNKNOWN Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Consortium
May 27, 2011·The New England Journal of Medicine·Johann S de BonoUNKNOWN COU-AA-301 Investigators
Jul 13, 2011·Cancer Research·Amy A LubikColleen C Nelson

❮ Previous
Next ❯

Citations

Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cale D FahrenholtzKerry L Burnstein
Jan 15, 2014·Cancer Metastasis Reviews·Jennifer Wu, Evan Yu
Sep 16, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MarousC Le Tourneau
Aug 2, 2015·Cancer Letters·Isabel HeideggerHelmut Klocker
Jun 25, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Isabel HeideggerHelmut Klocker
May 11, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·B J EiglK N Chi
Jan 15, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Lorente, J S De Bono
Aug 16, 2014·Cancer Treatment Reviews·Helen KingValentine M Macaulay
Nov 8, 2016·Expert Opinion on Biological Therapy·Panagiotis J VlachostergiosScott T Tagawa
Apr 8, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evan Y YuIan M Thompson
Jul 5, 2013·International Journal of Molecular Sciences·Colette GaletWilliam J Aronson
Nov 9, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kseniya MaslovaMaria Philippova
May 23, 2020·Expert Review of Endocrinology & Metabolism·Jeff M P HollyClaire M Perks
Feb 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johann S de BonoMichael N Pollak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.