A phase II study of 5-fluorouracil and high dose folinic acid in cisplatin-refractory metastatic bladder cancer

Annals of Oncology : Official Journal of the European Society for Medical Oncology
S D HuanD J Stewart

Abstract

Bladder cancer is a chemosensitive tumour, however, there is no effective therapy for patients with metastatic disease who failed to respond or relapsed after prior treatment with cisplatin-based chemotherapy. Single agent 5-fluorouracil has modest activity in bladder cancer. The combination of 5-fluorouracil with folinic acid results in stabilization of the ternary complex of 5-fluorodeoxyuridine monophosphate-thymidylate synthetase-5,10 methylene tetrahydrofolate leading to increased DNA inhibition and increased cytotoxicity of 5-fluorouracil. Fourteen evaluable patients with metastatic bladder cancer were treated with 5-fluorouracil at 300 mg/m2 and folinic acid at 200 mg/m2 daily for five days. There were no complete or partial responses. One patient had a minor response and three patients had stable disease. Diarrhea and mucositis occurred in 25% of patients. There was one treatment-related death. High dose folinic acid did not increase the cytotoxicity of 5-fluorouracil in metastatic bladder cancer after cisplatin failure.

Citations

Oct 26, 2013·Future Oncology·Christina Ann Ortmann, Danish Mazhar
Jun 25, 2009·Current Opinion in Urology·Mark Bachner, Maria De Santis
Sep 1, 1997·Seminars in Surgical Oncology·W M Brinkley, F M Torti

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