A Phase II study of oxaliplatin with low-dose leucovorin and bolus and continuous infusion 5-fluorouracil (modified FOLFOX-4) for gastric cancer patients with malignant ascites

Japanese Journal of Clinical Oncology
Sung Yong OhHyo-Jin Kim

Abstract

Clinical studies regarding chemotherapy for gastric cancer patients with malignant ascites have been classically rather limited in scope, largely because peritoneal seeding produces no measurable lesions, and patients generally exhibited poor performance status. Herein, we have evaluated the efficacy and toxicity of a fortnightly modified FOLFOX-4 (m-FOLFOX) regimen. Gastric cancer patients with cytologically confirmed malignant ascites were treated with cycles of oxaliplatin at 85 mg/m(2) plus leucovorin 20 mg/m(2) on the first day of treatment, followed by 5-fluorouracil (5-FU) via a 400 mg/m(2) bolus and a 22 h continuous infusion of 600 mg/m(2) 5-FU on Days 1-2 at 2-week intervals. Forty-eight patients participated in this study. Twenty-two patients (45.8%) were treated with m-FOLFOX-4 as a first line palliative treatment. Twenty-one patients (43.8%) were adjudged to have an Eastern Cooperative Oncology Group (ECOG) performance status of 2. Thirty-six patients were assessable and exhibited measurable lesions. Twelve (33.3%) patients evidenced partial responses. Decreases or disappearances of ascites levels were observed in 17 (35.4%) patients. The median time to progression and overall survival time were 3.5 (95% CI: 2.9-4....Continue Reading

Citations

Feb 18, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Haruhiko ImamotoHitoshi Shiozaki
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Satoru IwasaYasuhiro Shimada
Mar 1, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kohei ShitaraKei Muro
Sep 13, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ryutaro MoriWataru Yasui
Oct 16, 2010·International Journal of Clinical Oncology·Satoru IwasaYasuhiro Shimada
Sep 9, 2008·Current Treatment Options in Oncology·Michael Chung, Peter Kozuch
Jul 17, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H IshigamiH Nagawa
Dec 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheng-mao LuJian-wei Bi
Aug 29, 2013·Annals of Surgical Oncology·Reese W RandleKonstantinos I Votanopoulos
Dec 17, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Karol PolomFranco Roviello
Aug 17, 2010·Critical Reviews in Oncology/hematology·S BarniF Petrelli
Dec 17, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Dexter Yak Seng ChanWei Peng Yong
Jun 24, 2014·Expert Review of Anticancer Therapy·Marcelo GarridoAngel J Lacave
Jan 27, 2016·World Journal of Gastroenterology : WJG·Ramakrishnan Ayloor Seshadri, Olivier Glehen
Jul 1, 2020·Journal of Gastric Cancer·Daryl K A Chia, Jimmy B Y So
Oct 27, 2015·World Journal of Gastroenterology : WJG·Hiromichi MaedaJunichi Sakamoto
Oct 22, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Koji KonoJimmy So
Jun 5, 2018·Annals of Gastroenterological Surgery·Joji KitayamaNaohiro Sata
Jan 25, 2021·Surgery Today·Jun KinoshitaSachio Fushida

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