A phase II study of postoperative concurrent carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy followed by consolidation chemotherapy in surgically treated cervical cancer patients with positive pelvic lymph nodes

Gynecologic Oncology
Seiji MabuchiTadashi Kimura

Abstract

A phase II study was conducted to evaluate the efficacy and toxicity of carboplatin plus paclitaxel (TC)-based postoperative concurrent chemoradiotherapy (CCRT) followed by TC-based consolidation chemotherapy in surgically-treated early-stage cervical cancer patients. Women with surgically-treated early-stage cervical cancer with positive pelvic lymph nodes were eligible for this study. The patients were postoperatively treated with pelvic intensity modulated radiotherapy (50.4Gy) and concurrent weekly carboplatin (AUC: 2) and paclitaxel (35mg/m(2)) (TC-based CCRT). Three cycles of consolidation chemotherapy involving carboplatin (AUC: 5) and paclitaxel (175mg/m(2)) were administered after TC-based CCRT. Thirty-one patients were enrolled and treated. Overall, the treatment was well tolerated, and 26 patients (83.9%) completed the planned TC-based CCRT. The most frequently observed acute grade 3/4 hematological toxicities were leukopenia and neutropenia, and diarrhea was the most common acute grade 3/4 non-hematological toxicity. After a median follow-up period of 36.5months, 2 patients (6.5%) had developed recurrent disease. The patients' estimated 3-year progression-free survival (PFS) and overall survival (OS) rates were 88.5...Continue Reading

References

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Jul 10, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Seiji MabuchiTadashi Kimura
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Citations

Dec 9, 2016·Radiation Oncology Journal·Kyungmi YangJeong-Won Lee
Apr 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chen-Yang ZhaoZhong-Min Tian
Feb 16, 2018·International Journal of Clinical Oncology·Mika Okazawa-SakaiKazuhiro Takehara
Oct 11, 2019·International Journal of Molecular Sciences·Mizied FalahAnwar Rayan
Jun 22, 2019·BMC Molecular and Cell Biology·Yangyang HanMin Cheng
Mar 11, 2020·International Journal of Clinical Oncology·Yuri MatsumotoTadashi Kimura
Oct 20, 2018·Journal of Agricultural and Food Chemistry·Heting HouYi Wang

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