PMID: 9167758Jun 1, 1997Paper

A phase II study of topotecan in patients with recurrent head and neck cancer. Identification of an active new agent

American Journal of Clinical Oncology
F RobertR H Wheeler

Abstract

This study evaluated the efficacy and safety of topotecan, a topoisomerase I inhibitor, in patients with advanced squamous cell cancer of the head and neck. Topotecan was administered intravenously (over 30 min) daily for 5 days every 3 weeks at a starting dose of 1.5 mg/m2/day. Eligibility required no prior chemotherapy, measurable disease, and performance status of < or = 2. Quality of life (QOL) assessment was performed at specified time points using the Spitzer QOL index and the symptom distress scale. Of 26 patients entered into the study, 23 and 22 patients were assessable for toxicity and response, respectively. One complete and two partial responses were observed, with response durations of 9, 4, and 1.5 months, respectively. Six patients had stable disease, including one patient with a 45% tumor shrinkage. The median survival for all patients entered was 4 months. Neutropenia was the major dose-limiting side effect, with grade 4 toxicity observed in 42% of all cycles of treatment. Grade 3 anemia occurred in 16% of all cycles, and nine patients required blood transfusions. Nonhematologic toxicities were infrequent and mild to moderate. QOL assessment revealed no significant change of total scores between each assessment...Continue Reading

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Citations

Sep 21, 2007·Cancer Chemotherapy and Pharmacology·Francesco CaponigroPatricia Pollard
Oct 26, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Nuray Bayar MulukA Nur Cakar
May 5, 2001·Expert Opinion on Pharmacotherapy·B Arun, E P Frenkel
Mar 11, 2005·Oncology Nursing Forum·Teresa T Goodell, Lillian M Nail
Apr 2, 1999·International Journal of Oral and Maxillofacial Surgery·S N RogersJ A Woolgar
Jan 6, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Nuray Bayar MulukCan Koç
Oct 12, 2000·Medical and Pediatric Oncology·C Rodriguez-GalindoP J Houghton
Jun 1, 2004·American Journal of Clinical Oncology·Stephen M AnsellJoseph Rubin
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J NemunaitisD Kirn
Jan 7, 1999·The Annals of Pharmacotherapy·R J Cersosimo

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