A Phase II Study of Tumor Ablation in Patients with Metastatic Sarcoma Stable on Chemotherapy

The Oncologist
Angela C HirbeBrian A Van Tine

Abstract

Ablation therapy appears to be a reasonably safe and effective approach to obtain a significant treatment-free interval for a subset of patients with limited sites of metastatic disease for which systemic control can be obtained with six cycles of chemotherapy. Metastatic sarcoma often becomes resistant to treatment by chemotherapy. There is sometimes prolonged stable disease from active chemotherapy that provides a window of opportunity for an intervention to prolong disease-free survival. We performed a phase II study in patients with metastatic sarcoma who had been stable on six cycles of chemotherapy who then received ablation therapy to their residual disease. Histologies captured in this study included leiomyosarcoma, malignant peripheral nerve sheath tumor, pleiomorphic rhabdomyosarcoma, and myxoid liposarcoma. Sites ablated included lung metastases and retroperitoneal metastatic deposits. In this study, up to three lesions were ablated in any given interventional radiology session. After ablation, patients were not treated with any further therapy but were followed by surveillance imaging to determine progression-free rate (PFR). Although terminated early because of slow accrual, this study demonstrated a 3-month PFR of...Continue Reading

References

Jul 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J H EdmonsonD R Parkinson
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Van GlabbekeUNKNOWN EORTC Soft Tissue and Bone Sarcoma Group
Mar 19, 2005·Abdominal Imaging·Y NiG Marchal
Oct 18, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Caroline J SimonWilliam W Mayo-Smith
Jan 16, 2007·Journal of Surgical Oncology·Shinji OsadaKenichi Nonaka
Jan 17, 2007·Archives of Surgery·Alexander RehdersMatthias Peiper
Feb 3, 2009·International Journal of Surgery·Gianpaolo CarrafielloCarlo Fugazzola
Aug 25, 2009·The Annals of Thoracic Surgery·Shanda H BlackmonReza Mehran
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E WardelmannR Büttner
Jan 14, 2012·Clinical & Developmental Immunology·Sebastian P HaenCécile Gouttefangeas
Jul 7, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S SchurT Brodowicz
May 6, 2016·JAMA Oncology·Angela PangRobert G Maki
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Alessandro GronchiJoseph Patrick Erinjeri
Dec 6, 2016·Future Oncology·George D DemetriPaolo G Casali

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Citations

Feb 22, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jules LansuRick L Haas
Jul 3, 2021·Journal of Vascular and Interventional Radiology : JVIR·Anil Nicholas KurupMatthew R Callstrom
Sep 4, 2021·Journal of Vascular and Interventional Radiology : JVIR·Ankur DoshiGloria L Hwang

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT01986829

Software Mentioned

SAS

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