PMID: 15244251Jul 13, 2004Paper

A phase II study of UFT and Leucovorin in combination with mitomycin C in patients with metastatic colorectal cancer

Acta Oncologica
Niels GyldenkerneA Jakobsen

Abstract

The main objectives of this phase II study were to determine efficacy and safety of the combination of UFT with Leucovorin and mitomycin C in patients with metastatic colorectal cancer. Ninety-seven patients were treated with UFT (91 patients 300 mg/m2, 6 patients 250 mg/m2) + Leucovorin 90 mg days 1-28 q 5 weeks. During the first 4 cycles the patients also received mitomycin C 7 mg/m2 on day 1. At the end of 4 courses patients with benefit from the treatment could receive further courses of UFT and Leucovorin alone. Two patients had a complete response (2%), 20 (21%) had a partial response, 40 (41%) had no change, 19 (20%) had progression, and 16 (17%) were not evaluable for response. The overall response rate by intention to treat was 22/97 (23%). Median time to progression was 5 months and median survival 13 months. Severe (grade 3-4) toxicities included: anorexia 3%, nausea 6%, vomiting 7%, diarrhoea 7%, and fatigue 9%. Febrile neutropenia, renal failure, and thrombocytopenia were seen in 1% of the patients, respectively. The combination of UFT with Leucovorin and mitomycin C shows similar clinical activity with regard to overall response rate (23%) and survival (13 months) to other frontline 5-fluorouracil-based therapies ...Continue Reading

References

Dec 24, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P RossJ Oates
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Meta-analysis Group In CancerE Levy
Apr 29, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Herrmann
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·A K ChanD R Johnson
Jan 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M M BornerP Fumoleau

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Citations

May 4, 2010·Expert Opinion on Investigational Drugs·Anastasios DimouMuhammad Wasif Saif
Feb 15, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Renata FerrarottoPaulo M Hoff
Sep 29, 2017·International Journal of Clinical Oncology·Chiara BaratelliGiorgio Vittorio Scagliotti

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