PMID: 7860391Feb 15, 1995Paper

A phase II trial evaluating selective use of altered radiation dose and fractionation in patients with unresectable rhabdomyosarcoma

International Journal of Radiation Oncology, Biology, Physics
W F RegineL Kun

Abstract

Between 1987 and 1991, 25 children with advanced rhabdomyosarcoma (20 with IRS Group 3 disease and 5 with Group 4 disease) were entered on a prospective study evaluating selective use of hyperfractionated irradiation (HFI) and reduced-dose conventionally fractionated irradiation (CFI), based on disease status following induction chemotherapy (ifosfamide or melphalan, followed by vincristine, adriamycin, and cyclophosphamide combination) with or without delayed surgery. Patients with gross disease following induction chemotherapy with or without delayed surgery, and whose primary tumor sites did not involve the central nervous system, received HFI (n = 12) at 1.1 Gy twice-a-day to 59.4-63.8 Gy total. Patients with parameningeal primaries and intracranial disease extension received HFI with initiation of therapy (n = 2). Those with microscopic disease following induction chemotherapy with or without delayed surgery (n = 11) received reduced-dose CFI to 40 Gy. Active follow-up ranges from 28-75 months (median = 43 months) with no patient lost to follow-up. Eighteen patients (72%) are alive and without evidence of disease, including 8 of the children with gross residual disease postinduction therapy. The absolute 2-year continuous ...Continue Reading

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Citations

Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·S S DonaldsonE A Gehan
Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·L S ConstineE C Halperin
Jul 1, 1997·International Journal of Radiation Oncology, Biology, Physics·M D WharamH M Maurer
Oct 6, 1997·Journal of Pediatric Surgery·E L MichalkiewiczC B Pratt
Nov 15, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Lama JurdyPeerooz Saeed
Aug 5, 2000·Medical and Pediatric Oncology·J C Breneman, E S Wiener

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