A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosis

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Stephen M HahnEli Glatstein

Abstract

A previous phase I trial of i.p. photodynamic therapy established the maximally tolerated dose of Photofrin (Axcan Pharma, Birmingham, AL)-mediated photodynamic therapy and showed encouraging efficacy. The primary objectives of this phase II study were to determine the efficacy and toxicities of i.p. photodynamic therapy in patients with peritoneal carcinomatosis and sarcomatosis. Patients received Photofrin 2.5 mg/kg i.v. 48 hours before debulking surgery. Intraoperative laser light was delivered to the peritoneal surfaces of the abdomen and pelvis. The outcomes of interest were (a) complete response, (b) failure-free survival time, and (c) overall survival time. Photosensitizer levels in tumor and normal tissues were measured. One hundred patients were enrolled into one of three strata (33 ovarian, 37 gastrointestinal, and 30 sarcoma). Twenty-nine patients did not receive light treatment. All 100 patients had progressed by the time of statistical analysis. The median failure-free survival and overall survival by strata were ovarian, 2.1 and 20.1 months; gastrointestinal cancers, 1.8 and 11.1 months; sarcoma, 3.7 and 21.9 months. Substantial fluid shifts were observed postoperatively, and the major toxicities were related to v...Continue Reading

References

Feb 15, 1993·International Journal of Radiation Oncology, Biology, Physics·T F DeLaneyE Glatstein
Aug 1, 1997·Photochemistry and Photobiology·D A BellnierT J Dougherty
May 14, 1998·The Journal of Investigative Dermatology·K W WoodburnS W Young
Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Mar 21, 2003·The Annals of Thoracic Surgery·Joseph S FriedbergStephen M Hahn
Jun 10, 2003·Annals of Surgical Oncology·Robert J CanterDouglas L Fraker
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph S FriedbergStephen M Hahn
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Theresa M BuschSydney M Evans

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Citations

Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Feb 28, 2014·Proceedings of the National Academy of Sciences of the United States of America·Bryan Q SpringTayyaba Hasan
May 3, 2014·Photodiagnosis and Photodynamic Therapy·Laurie GuyonSerge Mordon
Mar 15, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Youssef MirTayyaba Hasan
Mar 1, 2012·Photodiagnosis and Photodynamic Therapy·Laurie GuyonSerge Mordon
Sep 23, 2010·Advanced Drug Delivery Reviews·Prakash RaiTayyaba Hasan
Aug 17, 2010·Critical Reviews in Oncology/hematology·S BarniF Petrelli
May 27, 2009·Journal of Photochemistry and Photobiology. B, Biology·Ole-Jacob NorumKristian Berg
Apr 19, 2007·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·G W Taylor, D G Jayne
Sep 25, 2012·Pediatric Blood & Cancer·Winston W HuhAndrea Hayes-Jordan
Nov 8, 2011·Lasers in Surgery and Medicine·Craig E GrossmanTheresa M Busch
Feb 28, 2013·Photochemistry and Photobiology·Imran RizviTayyaba Hasan
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Apr 10, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bryan Q SpringTayyaba Hasan
Jun 8, 2015·The Cancer Journal·Srivalleesha MallidiTayyaba Hasan
Jul 6, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pål Kristian SelboKristian Berg
Jun 8, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Pawel MrozMichael R Hamblin
Jun 22, 2016·Nanoscale·Girgis ObaidTayyaba Hasan
Jun 6, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Ole-Jacob NorumKristian Berg
Nov 11, 2017·Future Oncology·Henri AzaïsSerge Mordon
Feb 16, 2020·Photochemistry and Photobiology·Alexander Greer
Jul 8, 2020·Cancers·Dirk van den BrandWouter P R Verdurmen
Feb 16, 2020·Photochemistry and Photobiology·Gwendolyn M CramerKeith A Cengel
Feb 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kanwar R S GillLinda R Jones
Nov 25, 2014·Molecular Cancer Therapeutics·Kazuhide SatoHisataka Kobayashi
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen M HahnTheresa M Busch
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander Lin, Stephen M Hahn
Feb 18, 2020·Photodiagnosis and Photodynamic Therapy·Henri AzaïsSerge Mordon

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