A phase II trial of mitoxantrone plus cyclophosphamide and 5-fluorouracil in modulation with levo-folinate for advanced breast cancer patients

Journal of Chemotherapy
V LeonardiL Rausa

Abstract

Advanced breast cancer remains a major clinical problem. Current chemotherapy regimens are able to induce a clinical response in many patients but do not appear to influence significantly patients' survival. The use of new drugs such as mitoxantrone with a predicted lower toxicity and biochemical modulation of 5-fluorouracil with levo-folinate are extensively studied research areas that could combine good therapeutic efficacy with the maintenance of an acceptable quality of life. 34 patients with advanced breast carcinoma were included in the study. Only 4 women had received prior chemotherapy for advanced disease. Treatment plan was: 5-fluorouracil 400 mg/m2 + l-leucovorin 100 mg/m2 days 1-3, cyclophosphamide 600 mg/m2 and mitoxantrone 12-14 mg/m2 on day 3, q28. G-CSF (5 micrograms/kg/d days 7-14) was routinely delivered to the patients with the aim of maintaining dose intensity. 15 patients obtained a response for an overall response rate of 44%. Mean duration was 10.2+ and 11+ months for complete and partial responses respectively. Mean overall survival was 14.4+ months. A high complete response rate was seen in liver metastasis (44%), while lung lesions had a lower probability of response (25%). Toxicity was globally mild w...Continue Reading

References

Jun 7, 1976·Biochemical and Biophysical Research Communications·A L PogolottiD V Santi
Oct 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J D HainsworthF A Greco
Feb 1, 1991·American Journal of Clinical Oncology·C L LoprinziC J Allegra
Jul 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S M SwainC J Allegra
Apr 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J LokichJ G Fryer
Mar 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ErlichmanT Elhakim
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Clavel, G Catimel
Jan 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J D Hainsworth
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Carmo-PereiraE Henriques
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A Wils
May 1, 1993·The Annals of Thoracic Surgery·D A WyattC G Tribble

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May 5, 2018·Journal of Neurosciences in Rural Practice·Josef Finsterer, Sinda Zarrouk-Mahjoub

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