PMID: 8611446Apr 1, 1996Paper

A phase II trial of partially incompatible bone marrow transplantation for high-risk acute lymphoblastic leukaemia in children: prevention of graft rejection with anti-LFA-1 and anti-CD2 antibodies. Société Française de Greffe de Moelle Osseuse

British Journal of Haematology
M Cavazzana-CalvoA Fischer

Abstract

Bone marrow transplantation (BMT) from matched sibling donors has been useful for the treatment of acute lymphoblastic leukaemia in children with a poor prognosis but is not available to more than two-thirds of patients who do not have a matched allogeneic donor. This study was undertaken to assess one strategy of marrow graft rejection prevention when alternative marrow sources such as HLA-phenoidentical unrelated volunteers and HLA-partially incompatible relatives were used. Results have been compared with two matched groups of children with the same risks factors and disease status who underwent HLA-genoidentical or autologous BMT. The conditioning regimen was the same for the three groups of patients; in the study group anti-LFA-1 and anti-CD2 monoclonal antibodies combined with T-cell depletion of the marrow was added to prevent graft rejection and graft-versus-host disease. Nineteen patients were included and followed for a median of 25 months (14 months to 3 years). Bone marrow engraftment occurred in 83% of the evaluable patients. Post-transplantation infectious diseases were the most frequent causes of death in the study group, occurring in 31% of patients. No fatal infections occurred in the two control groups. Post-t...Continue Reading

Citations

Aug 7, 2012·Clinical & Experimental Metastasis·Jacob HochmanChi-Chao Chan
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tsukasa NabekuraAkira Shibuya
Jul 15, 2003·Clinical Microbiology Reviews·M van der FlierE I Tuomanen
May 3, 2011·American Journal of Respiratory and Critical Care Medicine·Angela Panoskaltsis-MortariUNKNOWN American Thoracic Society Committee on Idiopathic Pneumonia Syndrome
Apr 30, 2003·Expert Opinion on Biological Therapy·Russell L DedrickMarvin R Garovoy
Jul 7, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Behzad SoleimaniGabriele Weitz-Schmidt
Jan 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M R Nicolls, R G Gill
Jun 4, 2002·Human Reproduction·Catherine PoirotPierre Jouannet
Nov 19, 2004·Journal of Leukocyte Biology·Karyn Yonekawa, John M Harlan
May 12, 2009·Immunological Reviews·Mandy L Ford, Christian P Larsen
Dec 1, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nazia SelznerGary A Levy
Mar 17, 2007·The Journal of Dermatological Treatment·Amir A ToorKenneth B Gordon
Jun 1, 1997·Immunological Reviews·B R BlazarD A Vallera
Dec 10, 1999·Pediatric Transplantation·A Woolfrey, C Anasetti
Jun 9, 2004·Critical Reviews in Oncology/hematology·Renato BassanRoel Willemze

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Transplant International : Official Journal of the European Society for Organ Transplantation
H HorimotoM Nozawa
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
P MarchiG Masera
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
P C Harrison, J B Madwed
© 2021 Meta ULC. All rights reserved