A phase II trial of subcutaneous amifostine and radiation therapy in patients with head and neck cancer

Seminars in Radiation Oncology
Pramila Rani Anné, Walter J Curran

Abstract

This phase II trial was designed to verify that subcutaneous (SC) administration of Amifostine (Ethyol) protects against radiation therapy (RT)-induced xerostomia and ameliorates amifostine-related side effects (including nausea, vomiting, and hypotension). Patients receiving amifostine SC plus RT had a 56% incidence of acute xerostomia, comparable with previous phase III data with intravenous administration of amifostine. There was good tolerability, with cutaneous toxicity as the most significant side effect. These data suggest that amifostine SC provided comparable protection against RT-induced acute xerostomia as amifostine intravenously.

Citations

Nov 25, 2003·Journal of Applied Toxicology : JAT·Michael R LandauerThomas M Seed
Aug 25, 2004·The Journal of Pharmacy and Pharmacology·Sarala PamujulaTarun K Mandal
Jul 3, 2007·The Oncologist·John R KouvarisLampros J Vlahos
Jan 16, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mary P WalkerBrian Wichman
Apr 8, 2021·ACS Biomaterials Science & Engineering·Yahong LiuHongqi Tian

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