A phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
P C O'BrienJames W Denham

Abstract

A limited number of studies have suggested that oral sucralfate reduces the acute and late gastro-intestinal side-effects of pelvic radiotherapy and sucralfate enemas ameliorate symptoms of chronic proctitis. Sucralfate may act via local bFGF at the mucosal level in promoting angiogenesis and reducing epithelial associated microvascular injury. This multi-institutional study was designed to test the hypothesis that sucralfate given as an enema would have a significant protective effect against acute radiation induced rectal injury by direct application to the mucosa. Eighty-six patients having radiotherapy for localised carcinoma of the prostate were randomised in a double-blind placebo-controlled study to receive either 15 ml of placebo suspension or 3 g of sucralfate in 15 ml suspension, given as a once daily enema during and for 2 weeks following radiotherapy. Assessment was based on the EORTC/RTOG acute toxicity criteria and a patient self-assessment diary. There was no significant difference between placebo and sucralfate for peak incidences of EORTC/RTOG proctitis. For the placebo and sucralfate arms 95 and 88% (difference 7 +/- 11%) suffered some degree of proctitis, with 71 and 61% (difference 10 +/- 19%) reaching grade...Continue Reading

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·J Folkman, Y Shing
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Z FuksA Haimovitz-Friedman
Jun 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R HenrikssonB Littbrand
Jul 1, 1991·International Journal of Radiation Biology·D B RubinW F Ward
Aug 8, 1991·The American Journal of Medicine·S SzaboJ Folkman
Jan 1, 1990·International Journal of Radiation Oncology, Biology, Physics·W G SmitB H van der Werf-Messing
Jun 9, 1989·The American Journal of Medicine·S Szabo, D Hollander
May 1, 1985·Histopathology·P S HasletonP F Schofield
Apr 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·G E HanksB Epstein
Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·S VijayakumarG T Chen
May 1, 1996·Australasian Radiology·C I Franklin
Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·T E SchultheissG E Hanks

❮ Previous
Next ❯

Citations

Sep 10, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·N HovdenakO Dahl
Nov 22, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karin StellamansKarin Haustermans
Sep 18, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David S LambGillian Duchesne
Jul 1, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J W DenhamS Wright
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·N HovdenakM Hauer-Jensen
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·A KneeboneG Delaney
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Peter C O'BrienC Ian V Franklin
Aug 7, 2003·Seminars in Radiation Oncology·Martin Hauer-JensenJames W Denham
Jun 16, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M VentrucciG De Luca
Aug 8, 2001·The British Journal of Surgery·D HayneP B Boulos
Sep 13, 2001·Alimentary Pharmacology & Therapeutics·J J HongE D Ehrenpreis
Nov 17, 2000·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N Y HaboubiR J James
Feb 1, 2007·Clinics in Colon and Rectal Surgery·Gregory D Kennedy, Charles P Heise
May 18, 2000·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·J C Colwell, M Goldberg
Mar 8, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F AbbasakoorP B Boulos
Jan 1, 2009·Clinical and Experimental Gastroenterology·Somprakas BasuVijay K Shukla
Sep 11, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·He HuangYong-Qing Cao
Nov 13, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rachel J GibsonUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Sep 26, 2002·World Journal of Surgery·Yunus A GulKevin Moissinac
Dec 25, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Andrea HilleClemens-F Hess
Jun 19, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P C O'Brien
Jul 27, 2010·International Journal of Radiation Oncology, Biology, Physics·Te VuongSlobodan Devic
Dec 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Zvi SymonYehuda Chowers
Jul 18, 2008·Supportive Cancer Therapy·Martin Borg
Aug 5, 2008·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·John E BayouthGiuseppe Sanguineti
Mar 15, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·R VenkitaramanD P Dearnaley
Jul 2, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·M T W TeoC F Donnellan
Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Andrew KneeboneGeoff Delaney
Oct 7, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter C KoperPeter C Levendag
Dec 13, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kurian JonesWilfred Levin
Feb 28, 2014·Journal of Chemotherapy·James Wei Tatt TohCindy Chen
Aug 16, 2005·International Journal of Radiation Oncology, Biology, Physics·Christopher D JahrausWilliam H St Clair
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Carlos VargasJohn W Wong
Feb 24, 2001·Lancet·S Bydder
Nov 8, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David ChristieDana Bill
Dec 11, 2003·Revista do Hospital das Clínicas·Guilherme CottiAngelita Habr-Gama
Jan 24, 2018·The Cochrane Database of Systematic Reviews·Theresa A LawrieH Jervoise N Andreyev
Feb 11, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Lorenzo FuccioAlessandra Guido

❮ Previous
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