A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses

Breast Cancer Research and Treatment
David CameronCharles E Geyer

Abstract

Lapatinib is a small molecule, dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor type 2 (HER2). Initial results of a phase III trial demonstrated that lapatinib plus capecitabine is superior to capecitabine alone in women with HER2-positive advanced breast cancer that progressed following prior therapy including trastuzumab. Updated efficacy and initial biomarker results from this trial are reported. Women with HER2-positive, locally advanced or metastatic breast cancer previously treated with anthracycline-, taxane-, and trastuzumab-containing regimens were randomized to lapatinib 1,250 mg/day continuously plus capecitabine 2,000 mg/m(2) days 1-14 of a 21-day cycle or capecitabine 2,500 mg/m(2) on the same schedule. The primary endpoint was time to progression (TTP) as determined by an independent review panel. Relationship between progression-free survival (PFS) and tumor HER2 expression and serum levels of HER2 extracellular domain (ECD) were assessed. 399 women were randomized. The addition of lapatinib prolonged TTP with a hazard ratio (HR) of 0.57 (95% CI, 0.43-0.77; P < 0.001) and provided a trend toward improved overall survival (HR: 0.78, 95% CI: 0.55-1...Continue Reading

References

Jul 10, 1987·Science·P P Di FioreS A Aaronson
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H YamauchiD F Hayes
Dec 26, 2001·Journal of the National Cancer Institute·Y LuM Pollak
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francisco J EstevaGabriel N Hortobagyi
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael F PressLeslie Bernstein
Oct 21, 2005·The New England Journal of Medicine·Edward H RomondNorman Wolmark
Dec 29, 2006·The New England Journal of Medicine·Charles E GeyerDavid Cameron

❮ Previous
Next ❯

Citations

Jan 21, 2010·Cancer Chemotherapy and Pharmacology·April DavoliThomas L Brown
May 25, 2010·Archives of Gynecology and Obstetrics·Umut KefeliMahmut Gumus
May 3, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Linda S EltingUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Jun 28, 2011·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Thomas E DeleaDavid Cameron
Oct 31, 2009·Breast Cancer Research and Treatment·Bevan H LyGeorges Vlastos
Oct 12, 2010·Breast Cancer Research and Treatment·Jiyoung RheeTae-You Kim
Dec 27, 2011·Breast Cancer Research and Treatment·Hope S RugoMaura N Dickler
Mar 5, 2009·Journal of Mammary Gland Biology and Neoplasia·Philippe L BedardMartine J Piccart-Gebhart
Oct 21, 2011·Pharmaceutical Research·Kunal S TaskarQuentin R Smith
Jul 31, 2007·Current Treatment Options in Oncology·Amy Lin, Hope S Rugo
Aug 3, 2013·Current Treatment Options in Oncology·Jaclyn J Renfrow, Glenn J Lesser
Apr 15, 2008·Pathology Oncology Research : POR·László Kopper
Jul 18, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hiroji Iwata
Jun 2, 2011·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinji OhnoYoshiaki Nakamura
Feb 5, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Ricardo H Alvarez, Gabriel N Hortobagyi
Apr 15, 2009·Advances in Therapy·Heather McArthur
Dec 15, 2012·CNS Drugs·Rupert BartschMatthias Preusser
Nov 2, 2013·The Breast : Official Journal of the European Society of Mastology·Arjun Mehta, Debu Tripathy
Apr 6, 2013·Cancer Treatment Reviews·Lesley-Ann MartinGuy Jerusalem
Mar 10, 2011·Nature Medicine·Ian J Majewski, René Bernards
Apr 8, 2011·Nature Reviews. Cancer·Patricia S SteegQuentin R Smith
Dec 23, 2009·Nature Reviews. Clinical Oncology·Francisco J EstevaGabriel N Hortobagyi
Nov 30, 2011·Nature Reviews. Clinical Oncology·Carlos L ArteagaLuca Gianni
Apr 14, 2011·Nature Reviews. Clinical Oncology·April F EichlerRakesh K Jain
May 1, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B C Pestalozzi
Jul 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BeslijaUNKNOWN Central European Cooperative Oncology Group (CECOG)
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y KataokaH Minami
Sep 1, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T Pieńkowski, C C Zielinski
Dec 25, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E MontagnaM Colleoni
May 26, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J C SoriaT Le Chevalier
Jul 14, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G von MinckwitzUNKNOWN German Breast Group and Arbeitsgemeinschaft Gynäkologische Onkologie-Brust investigators
Aug 25, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Santoro, G Gullo
Aug 21, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MetroS Gori
Dec 2, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C A HarrisS Pearson
Mar 17, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y WuH J Burstein
Oct 13, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J LabonteH-J Lenz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

The New England Journal of Medicine
Charles E GeyerDavid Cameron
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Angelo Di LeoMichael Press
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Nancy U LinEric Winer
Annals of Oncology : Official Journal of the European Society for Medical Oncology
Harold J BursteinKimberly L Blackwell
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Stephen JohnstonMark D Pegram
© 2021 Meta ULC. All rights reserved