PMID: 11339427May 8, 2001Paper

A phase one study of the hepatic arterial administration of 1,25-dihydroxyvitamin D3 for liver cancers

Journal of Gastroenterology and Hepatology
I FinlayD L Morris

Abstract

It is well established that exposure to 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits the proliferation of human colorectal cancer and hepatoma cell lines, both in vitro and in vivo. However, clinical trials of the administration of 1,25(OH)2D3 and analogs for the treatment of malignancy have been limited by the development of hypercalcemia. 1,25-dihydroxyvitamin D3 is principally excreted in bile following hepatic catabolism. This suggested the hypothesis that hepatic regional administration may allow high doses of 1,25(OH)2D3 to be administered for the treatment of liver cancers without producing hypercalcemia, caused by a clinically significant first pass effect. This phase one study investigates the effect of hepatic regional administration of 1,25(OH)2D3 on serum calcium levels, together with other markers of renal and liver function. Six subjects with hepatic colorectal cancer metastases and one with primary hepatocellular cancer were given continuous hepatic arterial infusions of 1,25(OH)2D3, for periods of 1-4 weeks. Blood samples were taken regularly and assayed for calcium levels, liver function tests and urea and electrolyte levels. Patients remained normocalcemic at dosages of up to 10 mcg/day. No patient experien...Continue Reading

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Citations

Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·M H Pourgholami, D L Morris
May 18, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gerard E Mullin, Adrian Dobs
Nov 23, 2016·Development and Psychopathology·Todd D Little
May 2, 2006·Molecular Cancer Therapeutics·Sonoko Masuda, Glenville Jones
Jun 12, 2021·Frontiers in Oncology·Isaacson B AdelaniSolomon O Rotimi

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