A 'phenotypic hangover': the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome of Drosophila melanogaster

Environmental Epigenetics
Amy J Osborne, Peter K Dearden

Abstract

The Developmental Origins of Health and Disease hypothesis predicts that early-life environmental exposures can be detrimental to later-life health and that mismatch between the pre- and post-natal environment may contribute to the growing non-communicable disease epidemic. Within this is an increasingly recognized role for epigenetic mechanisms; for example, epigenetic modifications can be influenced by nutrition and can alter gene expression in mothers and offspring. Currently, there are few whole-genome transcriptional studies of response to nutritional alteration. Thus, we sought to explore how nutrition affects the expression of genes involved in epigenetic processes in Drosophila melanogaster. We manipulated Drosophila food macronutrient composition at the F0 generation, mismatched F1 offspring back to a standard diet and analysed the transcriptome of the F0-F3 generations by RNA sequencing. At F0, the altered (high-protein, low-carbohydrate) diet increased expression of genes classified as having roles in epigenetic processes, with co-ordinated down-regulation of genes involved in immunity, neurotransmission and neurodevelopment, oxidative stress and metabolism. Upon reversion to standard nutrition, mismatched F1 and F2 ...Continue Reading

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Citations

Feb 20, 2019·FEBS Letters·Pinreddy KarunakarAbhay Sharma
Jul 31, 2020·BMC Evolutionary Biology·Peter KlepsatelMartina Gáliková
May 14, 2019·Genes & Nutrition·Nieves Baenas, Anika E Wagner
Jan 9, 2019·Epigenetics & Chromatin·José L RuizElena Gómez-Díaz

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